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Diss Factsheets
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EC number: 203-820-9 | CAS number: 110-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
With high probability acutely not harmful to fish.
The toxicity of di-isopropanolamine to fish was tested in a study conducted in compliance with OECD test guideline 203, using Danio rerio as test species; the 96-h LC50 was determined to be 1466 mg/l in non-neutralized test solutions (nominal; calculated geometrical mean value; LC0 = 1000 mg/L, LC100 = 2150 mg/L). No difference regarding the toxicity of the substance was observed when replicates with pH adjusted test concentrations were used (BASF AG, 1995). This result is supported by a study conducted according to German Standard DIN 38412, part 15 testing the toxicity of the substance to Leuciscus idus in a static test system (BASF AG, 1987).
Short-term toxicity to aquatic invertebrates:
With high probability not acutely harmful to aquatic invertebrates.
The toxicity of di-isopropanolamine to Daphnia magna was determined in a static test conducted according to guideline 79/831/EEC, C.2. After 48 hours an EC50 of 277.7 mg/l was determined (nominal; not pH-adjusted; BASF AG, 1987).
Toxicity to aquatic algae and plants:
With high probability acutely not harmful to aquatic algae and cyanobacteria.
In the key study performed according to German standard DIN 38412, part 9 Scenedesmus subspicatus was exposed to di-isopropanolamine for 72 hours. At termination of the study an ErC50 of 339 mg/l was determined (72 -h ErC10 = 219 mg/L; BASF AG, 1988).
In contrast, an EC50 of 74 mg/l based on the growth rate of Selenastrum capricornutum was determined in a second study after 72 hours (Nagpal, 2003). However, these data are insufficient for the assessment, as no details on test performance are given.
Furthermore, Eide-Haugmo et al. (2012/2009) performed a guideline study according to ISO 10253 with the marine algae Skeletonema costatum. After 72 hours an ErC50 of 240.0 mg/L was determined.
Toxicity to microorganisms:
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
In a test performed according to ISO 8192 B, activated sludge (industrial) was exposed to di-isopropanolamine for 30 minutes and an EC20 of > 1995 mg/l was determined (BASF AG, 1981). In a test on Pseudomonas putida a toxicity threshold concentration of 15000 mg/l (equivalent to EC3) was determined (BASF AG, 1988).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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