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Diss Factsheets
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EC number: 270-695-5 | CAS number: 68476-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: inhalation
- Remarks:
- other: regulatory review
- Type of information:
- other: Recommendation from the Scientific Committee on Occupational Exposure Limits
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Science position underpinning EU occupational exposure limit for toluene
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Recommendation from the Scientific Committee on Occupational Exposure Limits for toluene
- Author:
- Scientific Committee on Occupational Exposure Limits
- Year:
- 2 001
- Bibliographic source:
- SCOEL/SUM/18 March 2001
- Reference Type:
- publication
- Title:
- Commission Directive 2006/15/EC of 7 February 2006 establishing a second list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC and amending Directives 91/322/EEC and 2000/39/EC
- Author:
- European Commission
- Year:
- 2 006
- Bibliographic source:
- Official Journal of the European Union L 38, 36-39
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
Test animals
- Species:
- other: human
Administration / exposure
- Route of administration:
- inhalation: vapour
Results and discussion
Effect levels
- Dose descriptor:
- other: 8 hr IOELV
- Effect level:
- 50 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: SCOEL concluded there was a great deal of human data demonstrating no reliable evidence of neurological effects at or below 50 ppm (192 mg/m3), hence 50 ppm was an appropriate level for an 8 hr TWA
- Remarks on result:
- other:
Applicant's summary and conclusion
- Executive summary:
SCOEL noted that toluene exposures in the range 90-150 ppm (345-575 mg/m3) for several hours lead to decrements in neurological test results although some of the findings were difficult to interpret due to uncertainties regarding the relationship between the effects monitored and contemporary / past levels of exposure. However the availability of a great deal of human data indicated no reliable evidence of effects at or below toluene concentrations of 50 ppm (192 mg/m3). SCOEL therefore concluded that 50 ppm (8 hour TWA) was an appropriate level for an IOELV.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.