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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral LD50: 1258 mg/kg bw for male rats and 988 mg/kg bw for female rats; Acute dermal LD50: 1500 mg/kg bw; Acute inhalative LC50=11 mg/m³
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 988 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 11 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 500 mg/kg bw
Additional information
In a non-guideline conform but nevertheless well conducted acute oral toxicity study (Flucke and Thyssen, 1981) fasted male Wistar rats were administered 100, 500, 750, 1000, 1500, 2000, and 2500 mg/kg bw test substance, while female rats of the same strains were applied 100, 250, 500, 600, 750, 1000, 1250, 1750, 2000 mg/kg bw 4-chlorophenol by gavage. The animals were observed for 14 days after administration. The acute oral LD50 was calculated to be 1258 mg/kg bw for male rats and 988 mg/kg bw for male rats. The following symptoms of poisoning occurred few minutes after the treatment: general behaviour disturbances (apathy), dyspnoea, convulsions, tremors and abdominal and lateral positions. Dyspnoea, cramps, abdominal and lateral positions were observed in the treatment of live animals up to 24 hours and the disturbance of general condition of up to 6 days after treatment.
A weight of evidence approach was used to determine the acute dermal and inhalation toxicity of 4-chlorophenol. In a non guideline but sufficiently conducted study (Flucke and Thyssen, 1981) the acute dermal toxicity of the test substance was investigated according to the method of Noakes and Sanderson (Brit. J. Ind. Med. 26, 59, 1969)
5 male and female rats were administered 1000, 2500 and 5000 mg/kg bw for 24 hours. The animals were observed for 14 days after administration. The animals were observed for 14 days after administration. No mortalities occurred. The acute dermal LD50 was calculated to be greater than 5000 mg/kg bw. No signs of clinical toxicity were reported. However, Gingell et al., 2001 (Patty´s Toxicology, John Wiley & Sons, p 11) reported the results of acute dermal study conducted in rats. The acute dermal LD50 resulted to be 1500 mg/kg bw.
A non-guideline inhalation study (limit test), which gives sufficient information on inhalation toxicity, was conducted on 5 male and female rats. The animals were exposed to 0.75 g/L of test substance in form of vapour. The animals were observed for 14 days after exposure. No mortality occurred during the study period. Rats showed signs of poisoning during exposure as agitation and slight irritation of nasal mucous membranes. Furthermore a slight increase in physiologically normal body weight was noted. Gross pathology investigation revealed the presence of lung disease ads dark red or grey coloured lungs and swollen region.
Gingell et al., 2001 (Patty´s Toxicology, John Wiley & Sons, p 11) reported the results of acute inhalation study conducted in rats. The acute inhalation LC50 resulted to 11 mg/m³.
Justification for classification or non-classification
The available data on acute toxicity of the test substance meet the criteria for classification as Acute Tox. 4, H302; Acute Tox. 4, H312; Acute Tox. 4, H332 according to Regulation (EC) 1272/2008 and as Xn, R22; Xn, R21; Xn, R20 according to Directive 67/548/EEC.
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