Registration Dossier
Registration Dossier
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EC number: 221-410-8 | CAS number: 3087-36-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable. Acute toxicity (48-h LC50) of the main decomposition product ethanol is used as a key value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5 012 mg/L
Additional information
When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than ethanol and hydrated titanium dioxide (half-life < 5 minutes, Brekelmans M.J.C. 2013). The organic decomposition product ethanol is readily biodegradable having also a low log Kow value (-0.3).
The CSA indicates that toxicity of this substance is similar to the main degradation product ethanol. Key studies (short-term toxicity to daphnia and algae, Klimisch score 1) conducted for the analogue category member (titanium tetraisopropanolate, CAS 546-68-9) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR.
Therefore, the key value for CSA is obtained from the lowest 48-h LC 50 (mortality) of ethanol to Ceriodaphnia dubia (peer-reviewed secondary source, Takahashi et al. 1987).
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