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EC number: 212-052-3 | CAS number: 756-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Evaluation of acute toxicity of the test substance after single I.V. application to rat animals
- GLP compliance:
- no
- Remarks:
- well documented study
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl methylphosphonate
- EC Number:
- 212-052-3
- EC Name:
- Dimethyl methylphosphonate
- Cas Number:
- 756-79-6
- Molecular formula:
- C3H9O3P
- IUPAC Name:
- dimethyl methylphosphonate
- Details on test material:
- - Name of test material (as cited in study report): FAT 80 021/B
No additional data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif RAIf strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: random bred rats raised on the premises of the testing facility were used for the experiments
- Age at study initiation: no data
- Weight at study initiation: 74 to 88 grams
- Fasting period: animals were fasted overnight before treatment
- Housing: on the day of the administration, the animals were randomised (HP 9810 Calculator) and distributed in groups of 5 into Macrolon cages (type 3) where they remained during the treatment and observation period
- Diet (e.g. ad libitum): standard diet of pellets - No. 890, Nafag Gossau SG
- Water (e.g. ad libitum): drinking water
- Acclimation period: a minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±1°C
- Humidity (%): 55±5%
- Photoperiod (hrs dark / hrs light): 14 hours light cycle day
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: distilled water
- Details on exposure:
- The animals were treated by slow intravenous injection (duration: 10 sec) into the tail vein. The concentration of the test substance in vehicle was 6%, 8%, 10%, 12% and 12% respectively for the 600, 800, 1000, 1200 and 1500 mg/kg bw dose groups.
- Doses:
- 600, 800, 1000, 1200 and 1500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
Physical condition and rate of death were monitored throughout the whole observation period. Autopsies were performed on those that died and on survivors at day 15 of the study. - Statistics:
- LD50 values including 95% confidence limits was calculated by the probit analysis method (Goulden A., Methods of Statistical Analysis, John Wiley and Sons, 1960, 3rd printing, pages 404-408.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 050 mg/kg bw
- 95% CL:
- 940 - 1 180
- Remarks on result:
- other: A total of 0/10, 2/10, 4/10, 6/10 and 10/10 animals died respectively, in the 600, 800, 1000, 1200 and 1500 mg/kg bw dose groups
- Mortality:
- Death occurred within 5 – 30 min in respiratory failure (see Table 1)
- Clinical signs:
- - In the 600 mg/kg bw group: after 5 min and lasting >60 min, reduction in spontaneous motility, ataxia, humpbacked, hyperventilation. After 3 hours no symptoms.
- In the 800, 1000, and 1200 mg/kg bw groups: same as for the 600 mg/kg bw group; additionally, laboured respiration, ventricurnbency, muscle twitches, humpbacked, roughening of the coat, restlessness. Tremor and cyanosis were further observed in the 1000 and 1200 mg/kg bw dose groups. - Body weight:
- no adverse effect recorded (see Table 1)
- Gross pathology:
- - In the 600 mg/kg bw group: no gross organ changes were seen.
- In the 800, 1000, 1200 and 1500 mg/kg bw groups: gross examination of the animals that died showed no pathology.
Any other information on results incl. tables
Table 1: Mortality and body weight
Dose level (mg/kg) |
Absolute mortality/total treated animal |
Mean body weight (g) |
|||
Males |
Females |
Day of test |
Pretest |
After 15 days |
|
600 |
0/5 |
0/5 |
- |
74 |
159 |
800 |
1/5 |
1/5 |
1 |
82 |
161 |
1000 |
3/5 |
1/5 |
1 |
82 |
176 |
1200 |
4/5 |
2/5 |
1 |
85 |
174 |
1500 |
5/5 |
5/5 |
1 |
88 |
- |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.