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Diss Factsheets
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EC number: 200-554-5 | CAS number: 63-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 to 11 Aug 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320:2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- Principles of method if other than guideline:
- - Initially observation to determine whether sieving of the material is required
- Malvern Mastersizer 2000 laser Diffraction Analyser - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 74.414 µm
- Geometric standard deviation:
- 1.35
- Key result
- Percentile:
- D50
- Mean:
- 78.074 µm
- Remarks on result:
- other: 10 % of the material is < 28.092 µm, 50 % of the material is < 68.504 µm and 90 % of material the is < 144.720 µm
- Mean:
- 78.074 µm
- Remarks on result:
- other: Volume weighted mean (mean value of 5 runs)
- Mean:
- 68.504 µm
- Remarks on result:
- other: Median (d.50) (mean value of 5 runs)
- Mean:
- 72.524 µm
- Remarks on result:
- other: Mode (mean value of 5 runs)
- Mean:
- 74.414 µm
- Remarks on result:
- other: MMAD (Mass Median Aerodynamic Diameter) (mean value of 5 runs)
- Conclusions:
- The MMAD (Mass Median Aerodynamic Diameter < 100 ¿m) has a mean value of 74.41 ¿m for Androst-4-ene-3,17-dione.
- Executive summary:
As the sample is believed to be toxic, the analysis was carried out using the `wet¿, small volume dispersion system. Several solvents were tried, in order to determine a suitable medium that provided maximum dispersability, but with minimum solubility. Silicone oil was finally selected as the most suitable dispersant. The particle size distribution was analysed over the range 0.02 µm to 2000 µm by the laser diffraction test. The median diameter (volume weighted mean) was 78.074µm. 3.89 % by volume of sample was seen to be < 10.00 µm. The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a mean value of 74.41 µm for Androst-4-ene-3,17-dione.
Reference
Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Validity criteria for the measurement of the granulometry:
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
Method B: The length and diameter distributions of fibres, if required, should be measured at least twice - using separate samplings and preparations - with at least 70 fibres per histogram. No two values in a given histogram interval should differ by more than 50 % or 3 fibres, whichever is larger. | Sample length measured at least twice. | Yes |
Method B: Full length (1) and diameter (d) data are needed on fibres of dimensions d ≥ 0.1 µm and 1 ≥ 5 µm. Two histogram distributions, based on examination of at least 50 fibres each, should be prepared. For diameters, the ranges should be 0.1 - 0.5, 0.5 - 1.0, 1 - 2, 2 - 3, 3 – 5 µm and over 5 µm. For lengths they should be 0 - 5, 5 - 10, 10 - 15, 15 - 20, (etc.) µm. | All values are measured. | Yes |
Method B: Number of particles per field and total number of fibres measured should be stated.
| Number is stated. | Yes. |
Description of key information
The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a mean value of 74.41 µm for Androst-4-ene-3,17-dione.
Additional information
Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus, repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
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