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EC number: 202-377-9 | CAS number: 94-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from a published study in a peer-reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology Update 2-Ethyl-1,3-hexanediol
- Author:
- Ballantyne B
- Year:
- 2 005
- Bibliographic source:
- J. Appl. Toxicol 25: 248-259
Materials and methods
- Type of study / information:
- skin irritation in humans
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Draize, 1944 skin irritation
- Principles of method if other than guideline:
- Single application patch testing with semi-occlusive or occlusive bandages was undertaken in human volunteers, to assess dermal irritation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexane-1,3-diol
- EC Number:
- 202-377-9
- EC Name:
- 2-ethylhexane-1,3-diol
- Cas Number:
- 94-96-2
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-ethylhexane-1,3-diol
- Test material form:
- liquid: viscous
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- the study involved semi-occlusive and occlusive patch testing of 136 human volunteers.
- Exposure assessment:
- measured
- Details on exposure:
- Primary irritation studies were conducted in human volunteers using 5% aqueous and undiluted EHD applied to the skin. Aqueous 5% EHD studies were conducted on 106 subjects (15 men and 91 women, aged 18–80 years). Two applications of solution soaked into 2.0 cm2 blotting paper were made to the infraclavicular skin: one application was covered with an occlusive dressing and the other with a semi-occlusive dressing. Patches were removed after 48 h and the sites evaluated immediately for local irritant effects and again 24 h later. A similar protocol was used for undiluted EHD with 30 subjects (3 men and 27 women, aged 18–80 years).
Results and discussion
- Results:
- Minor skin irritation was produced in approximately 13% of subjects having sustained cutaneous contact with undiluted EHD. In this group, barely perceptible erythema was observed in two subjects tested with semi-occlusive patches and four subjects with occlusion. Effects were seen at 48 and 72 h. An additional subject demonstrated a definite erythema at 72 h.
Milder reactions were observed using 5% aqueous EHD. Under semi-occlusive conditions only 1/106 subjects showed a barely perceptible erythema on removal of the dressing but not 24 h later. With occlusive conditions, only 1/106 subjects had barely perceptible erythema at 24 and 72 h.
Applicant's summary and conclusion
- Conclusions:
- Minor primary skin irritation may be produced upon exaggerated exposure of human subjects to 2-ethylhexane-1,3-Diol (EHD), with a greater response seen with undiluted EHD compared with 5% aqueous EHD.
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