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EC number: 232-164-6 | CAS number: 7789-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium bromide
- EC Number:
- 232-164-6
- EC Name:
- Calcium bromide
- Cas Number:
- 7789-41-5
- Molecular formula:
- CaBr2
- IUPAC Name:
- calcium bromide
- Details on test material:
- The test material was received from the Great Lakes Chemical Corporation, West Lafayette, Indiana on April 29, 1977. It was identified as "Calcium Bromide (solid), (417-130B), H1510ff and was received as a white powder.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Four male and 4 female Kew Zealand White rabbits were used for this study. The rabbits weighed from 2304 to 2934 grams at the beginning of this study. They were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters. They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals". Water and Purina Rabbit Chow were available ad libitum. Body weights were measured initially (control weight) and at 14 days.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: 20-30% of the body surface
- Type of wrap if used: The area of application was wrapped wirh gauze bandaging and occluded with Saran Wrap
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Twenty-four hours later the bandages were removed and the backs were washed with tepid tap water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 200 and 2000 mg/kg - Duration of exposure:
- 24 hours
- Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- The hair was removed from the back of each rabbit (20 - 30% of the body surface) with an electric clipper. The rabbits were divided into 2 groups of 2 male and 2 female rabbits each. The skin of one male and one female in each group was abraded with a scalpel blade. The abrasions penetrated the stratum corneum, but were not deep enough to cause bleeding. The test material was applied once only to the backs of the rabbits, using 0.9% physiological saline as the wetting agent, at the following dosage levels: 200 and 2000 mg/kg. The area of application was wrapped wirh gauze bandaging and occluded with Saran Wrap. Twenty-four hours later the bandages were removed and the backs were washed with tepid tap water. They vere observed at 24 hours and daily thereafter for a total of 14 days for mortality only.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: minimum lethal dose
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- CaBr2
- Mortality:
- One of 4 rabbits at the 2000 mg/kg dosage level died. None of the rabbits at the 200 mg/kg dosage level died during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The minimum lethal dose by the dermal route of administration was found to be less than 2000 mg/kg but greater than 200 mg/kg.
In accordance with the requirements of the Federal Hazardous Substances act this test material would not be considered a toxic substance by the dermal route of administration.
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