Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-194-1 | CAS number: 79-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
As the parent compound hydrolyses in water within 10 minutes the assessment of the biodegradability relates to the isobutyric acid and its structurally similar substances butyric acid, pentanoic acid, propionic acid and 2-ethyl hexanoic acid. The hydrolysis product turned out to be readily biodegradable (according to OECD criteria) by the use of a weight-of-evidence approach.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Parent compound isobutyryl chloride:
No experimental data are available for the parent compound. However, since the substance is known to hydrolyse very quickly to isobutyric acid and HCl, read-across is made to the supporting substances isobutyric acid (CAS 79 -31 -2), butyric acid (107 -92 -6), pentanoic acid (109 -52 -4), propionic acid (79 -09 -4) and 2 -ethyl hexanoic acid (149 -57 -5).
Isobutyric acid was tested in a Zahn-Wellens test similar to OECD TG 302 B (RL2) using activated sludge (source of the activated sludge was not specified). After 5 days, the test substance was degraded to 70% and after 10 days to >95% demonstrating the inherent biodegradability of the test substance (Hoechst AG, 1979).
In a test for ready biodegradability similar to OECD TG 301 E, isobutyric acid was shown to be readily biodegradable (Henkel KGaA, 1983). Due to insufficient documentation, the reliability for this test is hardly assignable. Nevertheless, the mentioned data was used for weight-of-evidence approach.
Butyric acid, pentanoic acid and propionic acid were evaluated within OECD SIDS dossiers and found to be readily biodegradable. This result is inter alia based on the findings by Dias & Alexander (1971) who tested the substances in Warburg respirometers following standard techniques which are similar to nowadays OECD TG 310 D. Butyric acid was also found to be easily biodegradable in a modified MITI (I) test which was similar to OECD TG 310C (Urano & Kato, 1986). The analogue substance 2 -ethylhexanoic acid, which is a more complex molecule than isobutyric acid, was determined to be readily biodegradable in a Modified OECD Screening Test following OECD 301E (Ekolab, 1998) .
The results above are supported by three QSAR models performed with isobutyric acid.
- EPI Suite v4.10: BIOWIN v4.10: Overall conclusion on ready biodegradability: readily biodegradable
- CATALOGIC v5.11.1: BOD 28 days MITI [OECD 301C] v3.04: ca. 100% after 28 d (domain similarity: 100%) - readily biodegradable
- CATALOGIC v5.11.1: BOD Kinetic [OECD 301F] beta v06.07: ca. 80% after 28 d (domain similarity: 100%) - readily biodegradable but failing
10 -day window
In a weight-of-evidence approach based on the results summmarised above, isobutyryl chloride and its hydrolysis product isobutyric acid are expected to be readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)