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EC number: 226-241-3 | CAS number: 5332-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 January 1990 - 5 March 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methoxypropylamine
- EC Number:
- 226-241-3
- EC Name:
- 3-methoxypropylamine
- Cas Number:
- 5332-73-0
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 3-methoxypropan-1-amine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 6398-24-1, Project #90-018
- Physical state: clear colorless liquid
- Analytical purity: responsibility of the Sponsor
- Stability under test conditions: no apparent change in the physical state of the test article during administration
- Other: specific gravity= 0.8725 g/ml
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc., Wilmington, Massachusetts
- Age at study initiation: young adults
- Mean weight at study initiation:
500 mg/kg dose group: males: 184.2 g, females: 175.0 g
800 mg/kg dose group: males: 266.6 g, females: 203.6 g
1250 mg/kg dose group: males: 260.6 g, females: 209.6 g
2000 mg/kg dose group: males: 254.6 g, females: 199.6 g
- Housing: individually in stainless steel 1/2" wire mesh cages, sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of
the Institute of Laboratory Animal Resources, National Research Council.
- Diet (e.g. ad libitum): Wayne Teklad Lab Blox, ad libitum
- Water (e.g. ad libitum): fresh tap water, ad libitum
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C±3°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12h dark/12h light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Not applicable
- Doses:
- Dose-range finding study: 500, 2500 and 5000 mg/kg
Definitive test: 500, 800, 1250 and 2000 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Viability was checked daily. Clinical effects were observed for at 1, 4 and 24h after dosing and once daily thereafter. Body weights were recorded at study initiation, days 7 and 14 or when found dead.
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculations performed via Litchfield and Wilcoxon on Pharmacological Calculations System, version 4.1.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 688.1 mg/kg bw
- 95% CL:
- 546.9 - 865.6
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 998.9 mg/kg bw
- 95% CL:
- 734 - 1 359.5
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 598.4 mg/kg bw
- 95% CL:
- 348.6 - 1 027.3
- Mortality:
- 2/10 animals died at the 500 mg/kg dose;
6/10 animals died at the 800mg/kg dose;
10/10 animals died at both the 1250 and 2000 mg/kg dose levels. - Clinical signs:
- other: Signs observed included decreased activity, piloerection, descreased muscle tone, abnormal gait, abnormal stance, diarrhea, chromodacryorrhea, dyspnea and prostration.
- Gross pathology:
- Necropsy of the animals dying on study: distended and/or fluid-filled stomachs and intestines, pale livers and pale kidneys.
Terminal necropsy of the remaining animals: distended fluid-filled intestines in one female rat.
Any other information on results incl. tables
Results of dose range finding study:
Signs observed included decreased activity, abnormal stance, abnormal gait, and dyspnea. None of the animals died at the 500 mg/kg dose level. Two of two animals died at both the 2500 and 5000 mg/kg dose levels. Based upon these results, a definitive LD50 study was performed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The Acute Oral LD50 in male and female rats for the substance was determined to be 688.1 mg/kg (95%CL of 546.9 to 865.6 mg/kg). Based on the results of this study and according to the criteria of the CLP Regulation the substance should be classified as a category 4 acute oral toxicant.
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