Registration Dossier
Registration Dossier
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EC number: 435-740-7 | CAS number: 94317-64-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 011
- Bibliographic source:
- NICNAS (Australia)
Materials and methods
Test guideline
- Guideline:
- EPA OPPTS 870.3100 (90-Day Oral Toxicity in Rodents)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 435-740-7
- EC Name:
- -
- Cas Number:
- 94317-64-3
- Molecular formula:
- C4H14N3PS
- IUPAC Name:
- Phosphorothioic triamide, N-butyl-
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral: diet
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily in diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0;200;1000;5000 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 15
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 74 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: 90 days
- Dose descriptor:
- LOAEL
- Effect level:
- 17 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: 90 days
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
