Registration Dossier
Registration Dossier
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EC number: 211-750-5 | CAS number: 693-36-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not considered to be B = bioaccumulative.
Key value for chemical safety assessment
Additional information
The high log Kow of this substance indicates a potential for bioaccumulation. However for various reasons bioaccumulation of aquatic organisms becomes unlikely:
1) The physico-chemical properties imply that water is not a target compartment (e.g. low water solubility and high adsorption).
2) The substance is readily biodegradable, but failing 10 window.
3) Calculations using BCFBAF v3.01 resulted low BCF values (regression based estimate: BCF = 3.16 L/kg; Arnot-Gobas method (including biotransformation rate estimates: BCF 0.893 L/kg upper trophic). A calculated BAF value indicates similar low accumulation properties as suggested by BCF(BCFBAF v3.01, Arnot-Gobas method, including biotransformation rate estimates, upper trophic: BAF 0.893 L/kg).
4) The maximum diameter is markedly above the OSIRIS cut-off criterion of 17Ä, with a diamax average of33.724Ä (OASIS Catalogic v5.11.19). Therefore, the substance is unlikely to cross biological membranes and to accumulate to a significant extend in biota.
In accordance with the Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment, these criteria are indicators for a limited bioaccumulation. Therefore the substance is not considered to be B = bioaccumulative.
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of (Q)SAR results were used for bioaccumulation.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on bioaccumulation are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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