Registration Dossier
Registration Dossier
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EC number: 200-658-0 | CAS number: 67-52-7
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Remarks:
- Two trophic levels and taxa were well investigated and covered. An additional study on aquatic invertebrates is scientifically not necessary and a QSAR prediction model using ECOSAR version 1.11 was applied instead
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction
ECOSAR class specific estimation (carbonyl ureas)
Data source
Reference
- Title:
- ECOSAR Version 1.11
- Author:
- ECOSAR v1.11, United States Environmental Protection Agency, Washington, DC, USA.
- Year:
- 2 013
- Bibliographic source:
- ECOSAR v1.11, United States Environmental Protection Agency, Washington, DC, USA.
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment, Chapter R.6: QSARs and grouping of chemicals
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Practical Guide, How to reoart (Q)SARs
- Version / remarks:
- version 3.1, July 2016
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Series on Testing and Assessment, No. 102
- GLP compliance:
- no
Test material
- Reference substance name:
- Barbituric acid
- EC Number:
- 200-658-0
- EC Name:
- Barbituric acid
- Cas Number:
- 67-52-7
- Molecular formula:
- C4H4N2O3
- IUPAC Name:
- pyrimidine-2,4,6(1H,3H,5H)-trione
- Details on test material:
- Target substance:
barbituric acid (CAS 67-52-7)
SMILES: C1(=O)CC(=O)NC(=O)N1
Catergory members used for read-across:
tetraacetylethylenediamine (CAS *0-09-6)
n-methyl-2-pyrrolidone (CAS 872-50-4)
2-piperidinone (CAS 675-20-7)
acetyl caprolactam (CAS 1888-91-1)
hexahydro-2h-azepin-2-one (CAS 105-60-2)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Study design
- Test type:
- not specified
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 12 964 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
