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EC number: 219-147-9 | CAS number: 2373-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted non-GLP, with limited data on study design, however the study was conducted according to state of the art methods at that time period. The study is considered adequate, reliable and relevant.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 1,4-bis(1,3-dimethylbutyl) sulphonatosuccinate
- EC Number:
- 219-147-9
- EC Name:
- Sodium 1,4-bis(1,3-dimethylbutyl) sulphonatosuccinate
- Cas Number:
- 2373-38-8
- Molecular formula:
- C16H30O7S.Na
- IUPAC Name:
- sodium 1,4-bis[(4-methylpentan-2-yl)oxy]-1,4-dioxobutane-2-sulfonate
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): Aerosol MA-80%, sodium dihexylsulfosuccinate
- Physical state: clear, viscous liquid (80% solution)
- Analytical purity: 78-80%
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Purity test date: Not provided
- Lot/batch No.: BV-1193A NH
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: good stability in aqueous solution
- Storage condition of test material: Not provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not provided
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Aerosol MA-80% was diluted with water to a solution of 5% solids.
The doses were 0.31 g/kg, 0.63 g/kg, 1.25 g/kg and 2.50 g/kg in terms of solids (active ingredient). - No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not provided
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- method of moving averages
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 750 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: no range calculable
- Mortality:
- All animals died within 24 hours following 2.5 g act. ingr./kg bw, but all survived at the lower dosages.
- Clinical signs:
- other: Following lethal doses the animals exhibited profound depression and severe diarrhea prior to death. At the lower dosages the animals were depressed to greater or lesser degree for 24 to 48 hours, but thereafter regained normal appearance and behavi
- Gross pathology:
- Moderate to severe irritation with hemorrhage of the gastrointestinal tract was found at post-mortem examination in the high dose group.
At autopsy there was a greater than usual distension of the intestines in some instances, but otherwise no significant gross findings in the other dose groups.
Any other information on results incl. tables
Table 1: Dosage & Results
Animal Number |
Body weight in Grams |
Weight Change in 7 Days |
Dosage in g act.ingr./kg bw |
Dose in Grams |
Dose in ml of Solution |
Days to Death |
R 9973 |
103 |
- |
2.50 |
0.26 |
5.2 |
<1 |
R 9974 |
109 |
- |
2.50 |
0.28 |
5.5 |
<1 |
R 9977 |
106 |
- |
2.50 |
0.27 |
5.3 |
<1 |
R 9979 |
94 |
- |
2.50 |
0.24 |
4.7 |
<1 |
R 9980 |
94 |
- |
2.50 |
0.24 |
4.7 |
<1 |
|
|
|
|
|
|
|
R 9982 |
101 |
10 |
1.25 |
0.13 |
2.5 |
S |
R 9983 |
90 |
25 |
1.25 |
0.12 |
2.3 |
S |
R 9985 |
90 |
24 |
1.25 |
0.12 |
2.3 |
S |
R 9988 |
101 |
24 |
1.25 |
0.13 |
2.5 |
S |
R 9989 |
116 |
40 |
1.25 |
0.15 |
2.9 |
S |
|
|
|
|
|
|
|
R 9990 |
91 |
22 |
0.63 |
0.06 |
1.14 |
S |
R 9993 |
99 |
6 |
0.63 |
0.06 |
1.24 |
S |
R 9995 |
96 |
6 |
0.63 |
0.06 |
1.20 |
S |
R 9996 |
101 |
14 |
0.63 |
0.06 |
1.26 |
S |
R 9997 |
108 |
19 |
0.63 |
0.07 |
1.35 |
S |
|
|
|
|
|
|
|
R 9998 |
96 |
12 |
0.31 |
0.03 |
0.61 |
S |
R 9999 |
98 |
12 |
0.31 |
0.03 |
0.62 |
S |
R 10000 |
100 |
37 |
0.31 |
0.03 |
0.63 |
S |
R 10001 |
90 |
19 |
0.31 |
0.03 |
0.57 |
S |
R 10002 |
97 |
13 |
0.31 |
0.03 |
0.61 |
S |
S= Survived
LD50=1.75 g/kg (No Range Calculable)
NOTE: For purposes of calculation of an LD50by the method of moving averages, a mortality of 5/5 at
5g/kg is assumed.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of Butanediodic acid, sulfo-, 1,4-bis(1,3-dimethylbutyl) ester, sodium salt is 1.75 g/kg in terms of solids content (active ingredient), and the test item is considered, therefore, to be a slightly toxic by ingestion at single dose. NOTE: For purposes of calculation of an LD50 by the method of moving averages, a mortality of 5/5 at 5g/kg bw is assumed.
- Executive summary:
The test item as received (80% solids) was diluted with water to a solution of 5% solids content (act. ingr.), and administered in single doses by gavage to groups of young, male albino rats at dosages ranging from 310, 630, 1250 and 2500 mg act. ingr./kg. All animals died within 24 hours following 2500 mg/kg, but all survived at the lower dosages. The acute oral LD50 was calculated to be 1750 mg active ingredient/kg with no confidence limits determinable. Following lethal doses the animals exhibited profound depression and severe diarrhea prior to death. Moderate to severe irritation with haemorrhage of the gastrointestinal tract was found at post-mortem examination. At the lower dosages the animals were depressed to greater or lesser degree for 24 to 48 hours, but thereafter regained normal appearance and behaviour. They were observed for a total of seven days following the dose, and then sacrificed. At autopsy there was a greater than usual distension of the intestines in some instances, but otherwise no significant gross findings.
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