Propanamide, 3-amino-2,2-dimethyl-

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Immediately move to fresh air. Consult a physician if

irritating symptoms develop and persist.

Emergency measure - Eyes: Rinse immediately with gently running water for 15 minutes,

maintaining eyelids open. Consult at once an ophthalmologist

or a physician.

Emergency measure - Skin: After contact with skin, wash immeditely with plenty of

water and soap. If skin irritation persists, call a

physician.

Emergency measure - Ingestion: Only as long as the patient is fully conscious: wash mouth

and have the victim drink copious amounts of water. Do not

induce vomiting. Consult a phyician if feeling sick.

Fire-fighting measures

Recommended extinguishing agent: The on-site fire crews would tackle any localized fire with

a dry powder extinguisher. If a major fire is involved, the

building sprinkler system would automatically activate. The

process drainage system is arranged such that all process

effluent is captured within a catchment pit which prevents

transfer to the site effluent treatment plant (ETP).  As

required, the contents of this pit can be transferred to a

holding  tank for subsequent analysis and despatch for

incineration.  If there is a risk of fume inhalation, the

firemen would wear breathing apparatus and fire-fighting

PPE.

Product arising from burning: Carbon oxides, nitrogen oxides

Product determined by test: N

Protective equipment: The on-site fire crews would tackle any localized fire with

a dry powder extinguisher. If a major fire is involved, the

building sprinkler system would automatically activate. The

process drainage system is arranged such that all process

effluent is captured within a catchment pit which prevents

transfer to the site effluent treatment plant (ETP).  As

required, the contents of this pit can be transferred to a

holding  tank for subsequent analysis and despatch for

incineration.  If there is a risk of fume inhalation, the

firemen would wear breathing apparatus and fire-fighting

PPE.

Accidental release measures

Emergency measures in case of spillage: In the event of spillage, the solid material will be

collected in dry form, sealed in a lined drum, labelled and

incinerated.  The subsequent water washings are isolated,

analysed and treated in the waste treatment unit or

incinerated depending on concentration.

Liquid spillages would be isolated in the catchment pit as

described above.

Handling and storage

Handling: Engineering:

Laminar flow exhaust ventilation with HEPA filtration and

vacuum-operated Powder Transfer System.

PPE:

Operators to wear;

Mechanical and chemical resistant gloves in line with EN 388

and EN 374

Chemical protective suit in line with EN 340

Full face mask in line with EN136 with ABEK-P3 filter (EN

141)

Storage: The enclosed substance, suitably labelled, will be stored

under cover in a warehouse unit at ambient temperature until

required for use in the production building. Only the

required amount for one batch will be transferred to the

production building at any one time.

Packaging of the substance and or preparation: The solid will be delivered in a triple-layered sealed bag

contained in a high density polyethylene keg containing,

25kg of product.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport code: RID/ADR: not restricted
Transport: Fork lift or hand lift trucks on pallet.

SpecialProvisions

Stability and reactivity

Danger other than fire: No known.

Chemical reaction with water: No known.

Dust explosion: not known

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: In view of the use of a significant stoichiometric excess of

the notifiable substance in the reaction mixture, a process

is being developed for the recovery of unchanged Synthon C

from the process waste.  However, this is not sufficiently

advanced to enable recovery to be carried out during the 5-

batch launch campaign in 2005.

Industry - Possibility of neutralisation: It is not anticipated that this will apply. Any unwanted

material would be incinerated at a licensed incineration

facility in the UK.

Industry - Possibility of destruction: controlled discharge: All process effluent will be contained, not allowed to enter

the environment and will be sent for incineration.

Industry - Possibility of destruction - incineration: All process effluent will be contained, not allowed to enter

the environment and will be sent for incineration.