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EC number: 426-790-0 | CAS number: 162208-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annev V
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- EC Number:
- 426-790-0
- EC Name:
- Diethyl thiophosphoryl (Z)-(2-aminothiazol-4-yl)methoxyimino acetate
- Cas Number:
- 162208-27-7
- Molecular formula:
- Hill formula: C10 H16 N3 O5 P S2
- IUPAC Name:
- diethoxy(sulfanylidene)-lambda5-phosphanyl (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetate
Constituent 1
Test animals
- Species:
- other: Rat (Sprague-Dawley origin)
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Aqueous methylcellulose
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 053 mg/kg bw
- 95% CL:
- 814 - 1 362
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- Signs of toxicity related to dose levels:
At 2000 mg/Kg all animals died or were sacrificed on humane
grounds by day 3. Two animals treated with 1000 mg/Kg/day
died within 24 hours of dosing. Clinical signs included
piloerection, hunched posture, waddling/unsteady gait,
abnormal respiration, pallid extremities, dark colouring to
eyes, lethargy, thin/ungroomed appearance, increased
sensitivity to touch, body tremors, increased salivation,
blue/cold extremities and protruding eyes among rats at all
dosages. Also observed was walking on toes and partially
closed eyelids (in rats at 2000 mg/Kg/day), increased
lacrimation (in rats at 500 and 1000 mg/Kg), abnormal
coloured urine (in rats at 500 and 2000 mg/Kg), abnormal
faeces (in rats at 1000 mg/Kg), prostration and convulsion
(clonic) and partially closed eyelids (in rats at 1000 and
2000 mg/Kg). Recovery of surviving rats was complete by Day
10. - Gross pathology:
- Effects on organs:
Macroscopic examination of decedents revealed congestive
changes in the majority of organs and tissues. There were no
macroscopic abnormalities observed among animals killed at
study termination. - Other findings:
- Signs of toxicity (local):
Transient slight irritation (erythema/oedema up to Grade 2)
notable in one or more animals at all dosages with
resolution complete in all instances by Day 5. This response
was accompanied by localised, patchy skin reactions
characterised by necrosis in one female and/or scabbing in
one further female.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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