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Diss Factsheets
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EC number: 218-059-8 | CAS number: 2044-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT (Transport-Classification) Guideliens
- Deviations:
- not specified
- Principles of method if other than guideline:
- The study was performed before GLP- and OECD-testing guidelines were available and in force.
- GLP compliance:
- no
- Remarks:
- GLP-guidelines not yet in force at date of the study
Test material
- Reference substance name:
- Acetoacet Dimethylamide
- IUPAC Name:
- Acetoacet Dimethylamide
- Reference substance name:
- N,N-dimethyl-3-oxobutyramide
- EC Number:
- 218-059-8
- EC Name:
- N,N-dimethyl-3-oxobutyramide
- Cas Number:
- 2044-64-6
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- N,N-dimethyl-3-oxobutyramide
- Test material form:
- other: liquid
- Details on test material:
- Physical state: liquid
The material to be tested 50% aqueous solution.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No information available.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Test Substance: 50% aqeous solution.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24 and 48 hours on intact and abraded skin.
- Number of animals:
- 6 rabbits were used for testing.
- Details on study design:
- The hair was clipped from the backs with the aid of angora clippers. Four areas of the back, placed approximately ten centimeters apart, were
designated for the positions of the patches. Areas 2 and 3 were abraded by making four epidermal incisions (two perpendicular to two others in the
area of the patch). The patches consisted of 1.5 inch x 1.5 inch 12 ply gauze squares. The patches ware secured to the area by thin bands of adhesivetape. The material to be tested (50% aqueous solution) was introduced beneath the patch. The entire trunks of the animals were then
wrapped in clear plastic trunk bands.
The trunk bands help to hold the patches in Position and retard evaporation of volatile substances during the four hour exposure period. Upon
removal of the patches the resulting reactions were evaluated on the basis of weighted scores.
Following this initial reading, all test sites were washed with appropriate solvent to prevent further exposure. Readings were again made at 24 and 48 hours after the initial application. The test substance was evaluated on a total of site (6 abraded and 6 intact).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hour
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours
- Score:
- 0
- Irritant / corrosive response data:
- No data available.
- Other effects:
- No data available.
Any other information on results incl. tables
The results were summarized below:
Observation |
Mean values over 4, 24 & 48 hours |
Mean value |
|||||
No.1 |
No.2 |
No.3 |
No.4 |
No.5 |
No.6 |
||
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance Acetoacet Dimethylamide was classified as non-irritant to skin.
- Executive summary:
The study was performed 1974, following the DOT (Transport Classification) Guidelines, before GLP- and OECD-testing guidelines were available and in force and amended in year 1991 (Addendum to Lonza Report No. 0003). The intact and abraded skin of albino rabbits was employed for this study. A series of 6 rabbits was used for testing.
No erythema and no oedema was observed in all 6 animals after 4, 24 and 48 hours observation period.
Therefore, the test item is considered not irritating to rabbit skin.
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