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Diss Factsheets
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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given. Review-like publication presenting studies on toxicokinetics as well as on acute toxicity, repeated dose toxicity, teratogenicity, and effects on endocrine organs in different species.
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption, Distribution and Toxicity of Ibuprofen.
- Author:
- Adams SS et al.
- Year:
- 1 969
- Bibliographic source:
- Toxicol Appl Pharmacol 15: 310-330.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data are given on test guidelines followed. However, the data is published in 1968; thus it can be assumed that there was no guideline available at the time period of testing.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Ibuprofen; i.e. 2-(4-isobutylphenyl)propionic acid)
- Analytical purity: no data
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male Boots Wistar rats
- Source: Boots
- Weight at study initiation: 70-95 g
- Fasting period before study: yes, food was withdrawn at 4-6 h prior to dosing
- Diet: ad libitum
- Water: ad libitum
No further data on test animals.
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 10% acacia, 0.4% cellosize, or 0.5% methylcellulose; no further details.
- Details on oral exposure:
- VEHICLE
The test substance was suspended in 10% acacia, 0.4% cellosize, or 0.5% methylcellulose.
No further details. - Doses:
- no data
- No. of animals per sex per dose:
- 10 males per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: mortality, gross reactions
no further data - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 600 mg/kg bw
- Remarks on result:
- other: The approximate LD50 was 1600 mg/kg bw.
- Mortality:
- Deaths occurred within 3 days from intestinal ulceration. No data are given on the mortality rate.
No further data. - Clinical signs:
- other: Clinical signs of toxicity comprised sedation, prostration, loss of righting reflex and labored respiration. No further data.
- Gross pathology:
- Intestinal ulceration was reported.
No further data.
Any other information on results incl. tables
According to the authors, the results of this study indicate that ibuprofen in lethal doses depressed the central nervous system of rats and was ulcerogenic. Ulcerogenesis may have been the result of systemic and local actions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Executive summary:
Ibuprofen induced gastrointestinal lesions in rats, the approximate lethal dose was 1600 mg/kg bw.
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