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EC number: 248-003-8 | CAS number: 26787-78-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: Test method OECD 203. No GLP. The LC50 (96h) was determined to be > 1000 mg/L based on mortality (nominal concentration).
Weight of evidence: Test method OECD 203. No GLP. The LC50 (96h) to zebrafish was determined to be > 100 mg/L based on mortality (nominal concentration).
Weight of evidence: Test method OECD 236 (draft). No GLP. The test item provoked premature hatching of embryos (48h-EC50 = 132.4 mg/L; nominal concentration).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
A short-term toxicity study to fish was performed by Park et al. (2008) according to OECD Guideline 203. Five Oryzias latipes juveniles (10-14 days) per dose and replicate (4 replicates) were exposed up to 1000 mg/L amoxicillin for 96 hours under semi-static conditions (test solution was changed after 48 hours). There is no data on analytical monitoring. The LC50 (96 h) was determined to be > 1000 mg/L based on mortality.
Oliveira et al. (2003) analysed the acute toxicity of amoxicillin in a Fish Embryo Acute Toxicity (FET) Test (Draft OECD Guideline 236) and in a Fish, Acute Toxicity Test (OECD Guideline 203). In the first one, zebrafish eggs were collected within 30 min after natural mating and exposed to 0, 75, 128, 221, 380, 654 and 1125 mg/L of amoxicillin. Ten eggs per treatment were distributed in 24-wells microplates in triplicate for 96 hours. The LC50 could not be determined since no mortality was observed (96h-LC > 1125 mg/L). The test item provoked premature hatching of embryos (48h-EC50 = 132.4 mg/L). The most frequent malformations due to amoxicillin exposure were oedemas and tail deformities. In the second study, 12 fish were divided in 3 replicates and exposed to 0, 11, 10, 25, 50 and 100 mg/L for 96 hours. No mortality was observed and the 96h-LC50 was determined to be > 100 mg/L. No data on analytics was reported in both tests. In the both studies the basal activities of enzymatic biomarkers were assessed (no guideline was followed). Tissues of adults and pools of embryos were used of catalase, glutathione-Stransferases and lactate dehydrogenase determinations. Amoxicillin inhibited catalase and induced glutathione-S-transferases in zebrafish adults. According to the authors, short-term effects were observed only at high doses indicating that physiological impairment in fish populations in unlikely to occur.
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