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Diss Factsheets
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EC number: 930-447-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March to june 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study by a laboratory having a GLP certificate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate on january 27th 2009
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- Concentrations of 25, 50, 75 and 100%
- No. of animals per dose:
- 4 animals for the preliminary test and 28 females for the main test.
Results and discussion
Any other information on results incl. tables
Due to the unsatisfactory solubility of the test item in the first recommended vehicle (acetone/olive oil (4/1, v/v)), dimethylformamide was chosen from the other proposed vehicles.
A solution was obtained at the maximum tested concentration of 75%.
Consequently, the concentrations selected for the preliminary test were 25, 50, 75 and 100%.
Since the test item was irritant in the preliminary test at the concentrations of 75 and 100%, the highest tested concentration retained for the main test was 50%.
Systemic clinical signs and mortality
Neither mortality nor clinical signs were observed during the study.
Local irritation
An erythema was noted on day 3 in 1/4 females treated at the concentration of 50% and on day 6 in 3/4 and 4/4 females treated at the concentrations of 25 and 50%, respectively. A dryness of the skin was also noted on day 6 in 1/4 females treated at the concentration of 2.5 or 5% and in all females treated at the concentration 10, 25 or 50%. A significant increase in ear thickness was observed in the animals treated at the concentration of 50%.
Proliferation assay
A significant lymphoproliferation was noted in the positive control group given HCA. The study was therefore considered valid.
A significant lymphoproliferation was noted at the tested concentrations of 25 and 50%.
The results are presented in the following table:
Treatment |
Concentration (%) |
Irritation level |
Stimulation Index (SI) |
Test item |
2.5 |
slightly irritant |
0.88 |
Test item |
5 |
non-irritant |
1.63 |
Test item |
10 |
non-irritant |
2.09 |
Test item |
25 |
slightly irritant |
6.96 |
Test item |
50 |
irritant |
9.01 |
HCA |
25 |
- |
5.79 |
In the absence of excessive local irritation at the concentration of 25%, the significant lymphoproliferative response observed at this concentration was attributed to delayed contact hypersensitivity.
The EC3 value for the test item EPOXY RESIN T1800 is equal to 13%.
Conclusion
Under the experimental conditions of this study, the test item EPOXY RESIN T1800 (batch No. 81016) induced delayed contact hypersensitivity in the murine Local Lymph Node Assay.
According to the EC3 value obtained in this experiment, the test item EPOXY RESIN T1800 should be considered as a weak sensitizer.
Applicant's summary and conclusion
- Interpretation of results:
- ambiguous
- Remarks:
- Migrated information
- Conclusions:
- Under the experimental conditions of this study, the test item EPOXY RESIN T1800 (batch No. 81016) induced delayed contact hypersensitivity in the murine Local Lymph Node Assay.
According to the EC3 value obtained in this experiment, the test item EPOXY RESIN T1800 should be considered as a weak sensitizer.
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