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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 216-913-4 | CAS number: 1696-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967-03-22 to 1967-04-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study predating guidelines and GLP, but scientifically fully acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- other: BASF test (close to Draize test), occlusive, 3 rabbits, intact skin, 20 h exposure (among others)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-acetylmorpholine
- EC Number:
- 216-913-4
- EC Name:
- 4-acetylmorpholine
- Cas Number:
- 1696-20-4
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- 1-(morpholin-4-yl)ethan-1-one
- Details on test material:
- - Name of test material: N-Acetylmorpholin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.83 kg (male); 3.10 kg (female); 2.72 kg (male)
ENVIRONMENTAL CONDITIONS
- no data
IN-LIFE DATES: From: 1967-03-29 To: 1967-04-14
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted (2 mL / animal (corresponds to 2.23 g)
- Duration of treatment / exposure:
- 1, 5 or 20 minutes
20 hours (data selected as worst case for 4 h test) - Observation period:
- Animal 1 (male, 7.6.645): 8 days, (day 3 and 4 lacking)
Animal 2 (female, 6.6.571): 5 days, (day 3 and 4 lacking)
Animal 3 (male, 5.6.427): 3 days - Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: at six sites per rabbit along the dorsum (plus left ear, not considered)
- % coverage: approximately 6 cm2 each
REMOVAL OF TEST SUBSTANCE
- Washing: yes, mild detergent (50% Lutrol)
SCORING SYSTEM: Draize score (converted from recorded grading with detailed instructions provided by data owner)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h, 48 h, and 5, 6, 7, 8 days (mean)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h, 48 h and 5 days (mean)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 h, 48 h, 72 h (mean)
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h, 48 h, and 5, 6, 7, 8 days (mean)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h, 48 h, and 5, 6, 7, 8 days (mean)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24 h, 48, 72 h (mean)
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Exposure duration 20 h (instead of 4 h, OECD 404)
- Irritant / corrosive response data:
- not irritating (minimal signs of skin irritation (erythema grade 1) were noted after the 20 h exposure period in one animal at the 24h and 48h reading).
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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