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EC number: 271-363-2 | CAS number: 68551-11-1 A complex combination of products produced by the distillation of products from the hydrogenation of butanal from the hydroformylation of propene. It consists predominantly of organic compounds such as aldehydes, alcohols, esters, ethers and carboxylic acids having carbon numbers in the range of C4-C32 and boiling in the range of approximately 143°C to 282°C (289°F to 540°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with analytical monitoring
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 740
- Physical state: Liquid, yellowish, turbid
- Analytical purity: 2-Ethylhexane-1,3-diol: 44 area-%
- Batch No.: continuous production
- Storage condition of test material: at ambient temperatures under N2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: 30 min before insertion of the test organisms (first and second interval) and at the end of the intervals
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test solutions were prepared separately for each test vessel and each interval. The test substance was homogenized by shaking. The test concentrations were stirred for 30 min to ensure that the test substance was completely dissolved.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebrafish
- Source: hatched at the testing facility
- Age at study initiation: ca. 3 months
- Length at study initiation (length definition, mean, range): from the top of the snout to the end of the caudal fin, 2.6 cm, 2.1- 2.9 cm
- Weight at study initiation (mean, range): 0.12 g, 0.05 - 0.16 g
- Feeding during test: no, withdrawal during the last day before start of exposure
ACCLIMATION
- Acclimation period: >= 14 days to test water, photoperiod and temperature
- Acclimation conditions: same as test
- Photoperiod: 16 hours light, 8 hours darkness
- Type and amount of food: Commercial fish diet "Tetramin", supplier Tetra-Werke, Melle, Germany
- Feeding frequency: ad libitum, additionally generally on workdays live brine shrimp (Artemia nauplii)
- Water quality: Non chlorinated charcoal filtered tap water, mixed with deionized water
- Total hardness: ca. 100 mg/L CaCO3
- Acid capacity: ca. 2.5 mM
- Oxygen content: > 80% saturation
- pH: generally 7.5 - 8.5
- Temperature: ca. 25 - 26 °C
- Mortality during the last week of exposure: > 5 %
- Medical treatment: none
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 100 mg/L CaCO3
- Test temperature:
- 23 °C
- pH:
- 7.9 - 8.3
- Dissolved oxygen:
- 6.3 - 8.5 mg/L
- Nominal and measured concentrations:
- Nominal test concentrations: control, 4.6, 10, 22, 46, 100 mg/L
Measured test concentrations (mean): -, 4.2, 9.1, 21.7, 44.2, 94.3 mg/L
Recovery rates: -, 91, 91, 99, 96, 94% - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: closed
- Material, fill volume: glass bottles covered with glass plugs, 10 L
- Aeration: none
- Renewal rate of test solution: after 48 hours
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.08 g fish/L water
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: non chlorinated charcoal filtered tap water mixed with deionized water
- Alkalinity: ca. 2.5 mM
- Ca/Mg ratio: 4: 1
- Conductivity: ca. 250 µS/cm (25 °C)
- Culture medium different from test medium: no
- Intervals of water quality measurement: Temperature, oxygen content and pH after 1, 24, 48 (new and old solutions), 72 and 96 hours
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light, 8 hours darkness
- Light intensity: ca. 100 - 490 Lux
EFFECT PARAMETERS MEASURED: mortality and toxic signs after 1, 6, 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.2
- Range finding study: yes
- Results used to determine the conditions for the definitive study: LC50 was between 10 and 100 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Measured effect concentrations after 96 hours:
LC0 = 44 mg/L
LC50 = 64 mg/L
LC100 = 94 mg/L
- Behavioural abnormalities:
- control: none
- 4.6 mg/L: none
- 10 mg/L: none
- 22 mg/L: none
- 46 mg/L: none
- 100 mg/L: tottering (1 h and 6 h, 3 fish); apathy (6 h and 24 h, 3 fish)
- Mortality of control: none - Results with reference substance (positive control):
- The median lethal concentration (LC50) were calculated using probit method based on Finney+ with SAS (version 8.2.) software.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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