Registration Dossier
Registration Dossier
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EC number: 219-956-7 | CAS number: 2582-30-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Subcutaneous application route is not relevant for humans.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Histamine toxicity in mice and rats following treatement with histaminase inhibitors
- Author:
- Angelakos ET, Loew ER
- Year:
- 1 957
- Bibliographic source:
- Pharmacol Exp therapy 119, 444-451, 1957
- Reference Type:
- review article or handbook
- Title:
- Potential Health Hazards of Existing Chemicals: Aminoguanidine bicarbonate
- Author:
- Berufsgenossenschaft der Chemischen Industrie
- Year:
- 1 999
- Bibliographic source:
- Toxicological Evaluations 15, 417-431, Springer Verlag
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single subcutaneous application and observation for clincal signs and mortality.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Test material form:
- other: solid
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- other: rats and mice
- Strain:
- other: Wistar rats and Swiss mice
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Doses:
- details not specified
- No. of animals per sex per dose:
- 10 rats and 20 mice
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 314 mg/kg bw
- 95% CL:
- >= 1 905 - <= 2 858
- Remarks on result:
- other: rat
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 770 mg/kg bw
- 95% CL:
- >= 1 497 - <= 2 042
- Remarks on result:
- other: mouse
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
