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Diss Factsheets
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EC number: 251-882-0 | CAS number: 34206-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 214.88 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- mobility
- Remarks on result:
- other: (Based on read-across approach from an analogue
- Details on results:
- Based on the experimental results obtained with the analogue substance butanone oxime (48h EC50 =201 mg/L ), the read-across approach is applied and the 48h EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 214.88 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental results on analogue butanone oxime, 48 -EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.
- Executive summary:
A Daphnia Acute Immobilisation Test was performed on analogue substance butanone oxime by the Ministry of Environment of Japan according to OECD TG 202. The 48h-EC50 was determined to be 201 mg/L. Based on these results, the read-across was applied and the 48 -EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.
Reference
Description of key information
Key study: Read-across from experimental data on analogue butanone oxime: The 48h-EC50 ofbutan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 214.88 mg/L
Additional information
Key study: Read-across approach from analogue butanone oxime:
Based on the read-across approach from experimental results on analogue butanone oxime (test method OECD 202, 48h-LC50 Daphnids = 201 mg/L), the 48h-EC50 of butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Daphnids was determined to be 214.88 mg/L.
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