Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.1tris (Akute-toxische-Klassen-Methode)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Vehicle:
other: 2 % Cremophor EL

Results and discussion

Effect levels
Sex:
male/female
Mortality:
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: 2000 mg/kg body weight, 20 min - 1 h: Piloerection, cyanosis, decreased motility, reactivity decreased, spasmodic state, erected tail and labored breathing. 300 mg/kg body weight, 20 min - 3 h: Spasm
Gross pathology:
Effects on organs:
2000 mg/kg body weight:

liver: dark-red

lung: pale

intestine: fluid, hemorrhagic

stomach: fluid, hemorrhagic

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU