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Diss Factsheets
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EC number: 239-816-9 | CAS number: 15721-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Assessment based upon available information.
- Adequacy of study:
- key study
- Study period:
- May 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Information selected for the toxicokinetic assessment is primarily study data. Studies were conducted inaccordance with recognised testing guidelines. While some studieswere not conducted according to GLP due to the age of the study and geographical location, all studies were conducted in reputable contract research organisations using specifically bred models that are fully validated for the types of study. All data used for the toxicokinetic assessment is rated at least 2 for relevance and reliability (based upon Klimisch, 1997) and were conducted upon the registered substance, bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine.
Data source
Reference
- Reference Type:
- other: Desk study
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- All available informaiton on bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine has been reviewed and assessed to produce a report on the toxicokinetics properties of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine
- EC Number:
- 239-816-9
- EC Name:
- Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine
- Cas Number:
- 15721-78-5
- Molecular formula:
- C28H43N
- IUPAC Name:
- 4-(2,4,4-trimethylpentan-2-yl)-N-[4-(2,4,4-trimethylpentan-2-yl)phenyl]aniline
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- SMILES : N(c(ccc(c1)C(CC(C)(C)C)(C)C)c1)c(ccc(c2)C(CC(C)(C)C)(C)C)c2
MOL FORMULA: C28 H43 N1
MOL WEIGHT : 393.66
Constituent 1
Results and discussion
Any other information on results incl. tables
The particle size of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine indicates that it is unlikely to be absorbed via the inhalation route (less than 10% 10µm), and based upon the above information bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not expected to be absorbed via the oral route in accordance with Lipinski's rule of five. The low water solubility and high Log Pow of the substance indicate that bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not easily absorbed in the body. No information is currently available on possible degradation products produced in the gastrointestinal tract. As bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is a solid powder with a very low water solubility (<0.1 mg/l), it is not expected to be absorbed via the dermal route.
During acute toxicity studies no systemic or local effects were noted at doses which humans are likely to come into contact.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Based upon the available data, bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is expected to have low potential for bioaccumulation.
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