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EC number: 700-213-5 | CAS number: 947753-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 11 March 2008 to 15 March 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to generally recognized standards and with GLP compliance. Chemical characterization, including purity and stability, lacking.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
- Type of study / information:
- Test to determine the potential of the test material to produce a photoxic response in human subjects.
- Principles of method if other than guideline:
- Exposure (occlusive) for 24 hours by patch test of health male and female volunteers to the test material (single application) followed at UVB and UVA irradiation of the treatment sites. Dermal scoring after 48 and 72 hours.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-ethylhexyl (2E)-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate; 2-ethylhexyl (2Z)-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
- EC Number:
- 700-213-5
- Cas Number:
- 947753-66-4
- Molecular formula:
- C25H29N03
- IUPAC Name:
- 2-ethylhexyl (2E)-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate; 2-ethylhexyl (2Z)-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
- Details on test material:
- Ethylhexyl methoxycrylene, Lot# ABP4-092007
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Inclusion criteria
Health male or female volunteers:
a) 18 to 65 years of age
b) Fair skinned with skin types I - IV, as follows:
I Always burns easily; never tans (sensitive)
II Always burns easily; tans minimally (sensitive)
III Burns moderately; always tans well (normal)
IV Rarely burns; tans profusely (insensitive)
V Never burns; deeply pigmented (insensitive)
c) Dependable and capable of following directions
d) Having completed a Medical History Form
e) Having read and understood and signed an Informed Consent Form
Exclusion criteria
a) Subjects with a history of abnormal response to sunlight
b) Subjects exhibiting current sunburn, suntan or uneven skin tone; which might interfere with the study evaluation
c) Pregnant or lactating women
d) Subjects taking medication which might interfere with the test results
e) Subjects who regularly use UVA sunbeds
f) Subjects exhibiting any visible skin disease which could be considered to affect the purpose and integrity of the study - Exposure assessment:
- not specified
- Details on exposure:
- Test method
Twenty-one (21) subjects were selected for participation.
Test site: The lower back, between the scapulae and the beltline, lateral to the midline, served as the treatment area. The area was free of sunburn, suntan, scars, active dermal lesions and uneven skin tones.
Light source: A Xenon Arc Solar Simulator (150w), producing a continuous light spectrum in the UVA and UVB regions (290-400 nm). A Schott WG 345 filter was used to block the sunburning UVB wavelengths (290-320 nm), allowing delivery of only UVA wavelengths (320-400 nm). Total dose of 20 joules.
Determination of Minimal Erythema Dose (MED): An MED is defined as the lowest time interval of dosage of UV light sufficient to produce defined erythema on designated test sites. Prior to the product test phase of the study, the MED of unprotected skin of each subject was determined by a progressive sequence of timed UV light expsoures, graduated incrementally by 25% over that of the previous exposure. The sites were evaluated for erythema according to the following scoring system:
0 = No visible reaction
0.5 = Barely perceptible or spotty erythema
1 = Mild erythema covering most of the test site
2 = Moderate erythema, possible presence of mild edema
3 = Marked erythema, possible edema
4 = Severe erythema, possible edema, vesiculation, bullae and/or ulceration
Treatment phase: On the first day of the study, three (3) test sites were outlined on the back with a skin marker. Two sites were treated with the test product, one to be irriadiated and one not. The third site remained untreated but was irradiated. Approximately 0.2 mL of the test material, or an amount sufficient to cover the area, was applied to a 3/4" x 3/4" gauze portion of an adhesive dressing. This was then applied to the appropriate treatment site to form an occluded patch. Twenty-four (24) hours after treatment, the patches were removed and the appropriate sites irradiated with 0.5 MED of UVB irradiation followed by 20 joules of UVA irradiation. All test and control sites were examined at 48 (48) hours and seventy-two (72) hours following irradiation and scored as described above.
Criteria for a positive response: Based upon the interpretation of erythemal responses as follows: If the degree of erythema/tanning noted on the treatment, irradiated site is significantly greater than that observed on the non-treatment, irradiated site, the test material may be judged phototoxic.
Results and discussion
- Results:
- All dermal responses at all time points measured were 0.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, ethylhexyl methoxycrylene, Lot# ABP4-092007, did not induce a response indicative of a phototoxic reaction.
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