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EC number: 420-670-1 | CAS number: 37443-42-8 METHFAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 24 April 1996 to 26 April 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl tetrahydro-2-furancarboxylate
- EC Number:
- 420-670-1
- EC Name:
- Methyl tetrahydro-2-furancarboxylate
- Cas Number:
- 37443-42-8
- Molecular formula:
- C6H10O3
- IUPAC Name:
- methyl oxolane-3-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- Identity: Methfat
Chemical name: Methyl tetrahydro-2-furoate
Batch number: 17-5C03 (GLFC No.002)
Expiry: 7 November 1996
Purity: 99.4%
Appearance: Clear liquid
Storage conditions: In darkness at room temperature
Date received: 17 November 1995
Constituent 1
Test solutions
- Details on test solutions:
- Method of preparation
Elendt M7 medium was prepared using analytical grade reagents and reverse osmosis purified water.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Culture:
Brood stocks of Daphnia magna were cultured under a 16 h light : 8 h dark photoperiod at 20°C in polypropylene vessels containing two litres of Elendt M7 medium. Cultures were fed daily with a suspension of mixed algae (predominantly Scenedesmus and Selenastrum spp). Culture conditions ensure that reproduction is by partbenogenesis.
Gravid adults were isolated 24 hours prior to initiation of the test. Young daphnids produced overnight were used for testing.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19+/-1°C
- pH:
- From 7.5 to 7.9
- Dissolved oxygen:
- From 7.8 to 8.4 mg O2/l
- Nominal and measured concentrations:
- Nominal concentrations: 2.2. 4.6. 10. 22. 46. 100 and 220 mg/l
Mean measured concentrations: 1.7. 3.7. 8.5. 19. 42, 93 and 200 mg/l - Details on test conditions:
- Experimental design
Seven test concentrations plus one control each in duplicate (20 animals per test group).
Ten first instar Daphnia were placed at random in each glass jar containing 200 ml of prepared test medium, or diluent medium only, as appropriate, to give a loading of 20 ml test solution per organism. The jars were sealed with screw-down lids to minimise evaporation losses.
Environmental conditions
Cultures were maintained at 19 ± I °C under a photoperiod of 16 hours light : 8 hours dark and without supplementary aeration or feeding during the 48 hour exposure period.
The temperature in each vessel was measured daily and the pH and dissolved oxygen levels recorded at the start and at the end of the study.
Criterion of effect
Daphnia were considered to be immobilised if they were unable to swim after approximately 15 seconds of gentle agitation.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- There was no incidence of significant immobilisation recorded in any of the test or control vessels during this study (see Table I). All results are expressed in terms of mean measured concentration, which for the highest concentration tested was 93% of nominal.
The measured concentration concentration at the highest test level (220 mg/l) ranged from 99% of nominal at 0 hours to 87% of nominal at 48 hours. demonstrating that near nominal concentrations were achieved and maintained during this study.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48h EC50 (immobilisation) value for Methfat with Daphnia magna is > 200 mg/l.
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