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Diss Factsheets
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EC number: 203-273-6 | CAS number: 105-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Oleaginous yeast, Lipomyces starkeyi (IFO10381) was maintained on YM agar. The compound as a methanol solution was added to 5 mL of broth in a test tube to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol at the start of the culture. As a control, 1% methanol was added to the broth. Yeasts were cultivated using a rotary shaker (120 rpm) at 27 °C for 7 days
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- The compound was used as a methanol solution to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol.
- Test organisms (species):
- other: Lipomyces starkeyi IFO10381
- Details on inoculum:
- Oleaginous yeast, Lipomyces starkeyi IFO10381 (IFO, Osaka, Japan) was maintained on YM agar at 25 °C. One loopful of yeast well grown on a YM agar slant was inoculated into 5 mL of YM broth and cultivated with 120 rpm rotary shaking at 27 °C for 2 days. The precultured broth was inoculated with 1% (v/v) inoculum into the MLA broth
- Test type:
- semi-static
- Water media type:
- not specified
- Total exposure duration:
- 7 d
- Test temperature:
- 27 °C
- Nominal and measured concentrations:
- 20 and 200 mg/L
- Details on test conditions:
- The compound as a methanol solution was added to 5 mL of broth in a test tube to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol at the start of the culture. As a control, 1% methanol was added to the broth. Yeasts were cultivated using a rotary shaker (120 rpm) at 27 °C for 7 days
- Duration:
- 7 d
- Dose descriptor:
- other: EC14
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- dissolved
- Basis for effect:
- growth inhibition
- Remarks:
- inhibited fungal growth by 14%
- Duration:
- 7 d
- Dose descriptor:
- other: EC14
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- dissolved
- Basis for effect:
- growth inhibition
- Remarks:
- inhibited fungal growth by 14%
- Conclusions:
- Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
- Executive summary:
Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
Reference
Description of key information
Toxicity to microorganisms:
Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 200 mg/L
Additional information
Toxicity to microorganisms:
Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
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