Registration Dossier
Registration Dossier
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EC number: 231-293-5 | CAS number: 7486-38-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Based on the absence of data for disodium adipate, results from the corresponding acid are taken into account for this endpoint. The toxicity of adipic acid on growth of Tetrahymena pyriformis was testsed in a 40 h test. An EC50 of 591.02 mg/l was observed (Schultz, 1997).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 591.02 mg/L
Additional information
Based on the absence of data for disodium adipate, a read-across approach with adipic acid is applied. In aqueous media, disodium adipate and adipic acid acid dissociate into the corresponding anion (1,6-hexandioic acid ion) and the sodium ion and hydrogen ion (proton), respectively. Fate, behavior and the ecotoxicological properties of adipic acid and its disodium salt are thought to be an effect of the di-carboxylate ion rather than of the sodium ion or the hydrogen ion (proton), which are normal constituents in environmental systems and have no relevant ecotoxic properties in low concentrations. Therefore a read-across between disodium adipate and adipic acid is justified.
There are no tests of pure adipic acid with a mixed inoculum that assess the functioning of the entire microbial community in an STP available. A test with activated sludge exists with a duration of 3 hours using a residue from adipic acid manufacturing containing 60 % adipic acid performed according to the OECD TG 209 (Activated Sludge, Respiration Inhibition Test) (Bayer, 1988). With regard to pure adipic acid only tests based on single species are available.
In a 17 hours test with adipic acid towards Pseudomonas putida according to the German standard method DIN-38412 Part 8 (Cell Multiplication Inhibition Test), an EC50 of 91.9 mg/l was observed (BASF AG 1987). But in this test the pH values in the test solutions ranged from 4.65 (125 mg/l) to 7.02 (3.91 mg/l). As at higher concentrations tested the pH was <5, it cannot be excluded that the toxicity observed was due to pH effects. Therefore, the study is stated to be reliable, but should not be used for the hazard assessment.
A test on growth impairment with Tetrahymena pyriformis (Schultz, 1997) using adipic acid as test substance, results in an inhibitory growth concentration (IGC50) of 591.02 mg/L after 40 hours.
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