Registration Dossier
Registration Dossier
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EC number: 227-770-2 | CAS number: 5973-71-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 value is 7.2 mg/L in Oncorhynchus mykiss (rainbow trout).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.2 mg/L
Additional information
The short-term toxicity to fish was examined in a study in accordance with OECD guideline 203 and in compliance with GLP criteria (Safepharm Laboratories Ltd, 2007). In this study, groups of 7 fish (O. mykiss) were exposed to nominal test concentrations of 0 (control), 1.8, 3.2, 5.6, 10, and 18 mg/L for a period of 96 hours under semi-static conditions (24 -h renewal periods). The number of mortalities and any sub-lethal effects were recorded regularly throughout the test. Nominal test concentrations were analytically verified at the start and at the end of each test medium renewal period. As there was a general trend for a decline in measured test concentrations, results were based on the time weighted mean measured test concentrations of the test media. The measured concentrations were determined at 2.0, 3.3, 5.2, 9.9 and 17 mg/L. Deaths were first observed at the two highest tested concentrations with 96 -h cumulative mortalities of 100%. No deaths were observed at any of the lower tested concentrations. Based on these findings, the 96 -h LC50 value was determined at 7.2 mg/L (based on measured concentrations).
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