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EC number: 219-110-7 | CAS number: 2362-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4'-cyclohexylidenedi-o-cresol
- EC Number:
- 219-110-7
- EC Name:
- 4,4'-cyclohexylidenedi-o-cresol
- Cas Number:
- 2362-14-3
- Molecular formula:
- C20-H24-O2
- IUPAC Name:
- 4-[1-(4-hydroxy-3-methylphenyl)cyclohexyl]-2-methylphenol
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Dimethyl cyclohexyl bisphenol (DMBPC; CAS No. 2362-14-3)
- Synonyms: Dimethyl bisphenolcyclohexane; 4,4’-cyclohexylidene di-o-cresol; 1,1-Bis(4-hydroxy-3-ethyl)cyclohexane; Bis-OC-Z
- Appearance: fine white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Six outbred albino rats per sex were received from the supplier. Female rats were nulliparous and non-pregnant. They weighed 216.5-247.8 g and were at least 8 weeks old at the start of the study. They were single housed upon arrival in polycarbonate cages with hardwood chip bedding. The animals were acclimated for at least 5 days prior to dosing. Tap water was provided ad libitum throughout the study and feed was provided ad libitum, with the exception of overnight prior to dosing. The temperature and humidity were maintained at 68 ± 5 °F and 30 - 70 %, respectively. Room lights were on a 12-hour light/dark cycle.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: methanol
- Details on oral exposure:
- DMBPC was dissolved in methanol prior to dosing. The dosing volume did not exceed 1 mL/100 g body weight.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Food was withheld from the animals the night prior to dosing. Animals were administered a single dose of DMBPC by oral gavage. After dosing, the animals were returned to their cages and supplied with feed and water ad libitum.
Careful clinical observations were made at least twice on the day of dosing. Animals were observed daily for 14 days for clinical manifestations. Animals were weighed on Day 0 (prior to dose administration), Day 7 and Day 14.
On Day 14 animals were sacrificed by CO2 inhalation and a gross necropsy was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the duration of the study.
- Clinical signs:
- other: No clinical signs of toxicity were observed in any animals over the course of the study.
- Gross pathology:
- No unusual findings were found during necropsy for the animals euthanised at study termination.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to EU criteria
- Conclusions:
- Under the conditions of this study, DMBPC was determined to have an acute oral LD50 of greater than 2000 mg/kg.
- Executive summary:
The acute toxicity potential of the test material was investigated in a study conducted in accordance with the standardised guidelines OECD 423 and EPA OPPTS 870.1100 under GLP conditions using the acute toxic class method.
Six Sprague-Dawley rats were exposed to the test material at a limit dose of 2000 mg/kg bw in methanol by oral gavage.
Careful clinical observations were made at least twice on the day of dosing. Animals were observed daily for 14 days for clinical manifestations. Animals were weighed on Day 0 (prior to dose administration), Day 7 and Day 14. On Day 14, animals were sacrificed by CO₂ inhalation and a gross necropsy was performed.
All animals survived the duration of the study. No clinical signs of toxicity were observed in any animals over the course of the study and all animals gained weight over the course of the study. No unusual findings were found during necropsy for the animals euthanised at study termination.
Under the conditions of this study, DMBPC was determined to have an acute oral LD50 of greater than 2000 mg/kg.
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