Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-863-9 | CAS number: 2921-57-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate) is an intermediate in the Methylprednisolone synthesis.
Methylprednisolone is a glucocorticoid.
Additional information
No reproductive toxicity studies are available on 11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate), but Glucocorticoid medication use during pregnancy has been associated in some but not all studies with an increased risk of cleft palate and impaired fetal growth.
Justification for classification or non-classification
Based on available data on glucocorticoids, the intermediate "11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione 21-(hydrogen succinate" was classified as toxic to reproduction cat. 1B, H360D (May damage the unborn child).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
