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EC number: 251-201-7 | CAS number: 32764-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP study following a method similar to the Buehler method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Tetrahydro-6-(3-pentenyl)-2H-pyran-2-one
- EC Number:
- 251-201-7
- EC Name:
- Tetrahydro-6-(3-pentenyl)-2H-pyran-2-one
- Cas Number:
- 32764-98-0
- Molecular formula:
- C10H16O2
- IUPAC Name:
- tetrahydro-6-(3-pentenyl)-2H-pyran-2-one
- Test material form:
- not specified
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 300 - 414g
- Housing: in metal cages of the suspended type with wire mesh floors.
- Diet (e.g. ad libitum): pellet diet supplemented with vitamin C ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- propylene glycol
- Concentration / amount:
- 10%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- propylene glycol
- Concentration / amount:
- 10%
- No. of animals per dose:
- 11
- Details on study design:
- Prior to each application of the test material, the hair was close clipped from the inter-scapular region using electric clippers. The test material was applied, at a volume of 0. 1 ml on a half inch square of surgical gauze, to the clipped inter-scapular region of the guinea-pigs in each group. The treatment area was then covered with an impervious elastic bandage ("Elastoplast" backed with "Sleek" plaster). Contact with the skin was maintained for 24 hours, when the dressings were removed and the resulting dermal response evaluated. After an incubation period of two weeks, a final challenge dose was applled.
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: not reported
- Group:
- test chemical
- Dose level:
- 10% test material
- No. with + reactions:
- 0
- Total no. in group:
- 11
- Remarks on result:
- other: Reading: other: not reported. Group: test group. Dose level: 10% test material. No with. + reactions: 0.0. Total no. in groups: 11.0.
Any other information on results incl. tables
No reactions were observed in any test animal.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this test, the test material is not considered to be a skin sensitiser.
- Executive summary:
The study was performed to assess the skin sensitisation potential of the test material in the Hartley strain guinea pigs following the buehler method. The study was performed pre-GLP and following a method similar to OECD Guideline 406. For the epicutaneous induction and challenge application, a concentration of 10% was used. A group of 11 test animals received induction doses by topical application. Prior to each application of the test material, the hair was close clipped from the inter-scapular region using electric clippers. The test material was applied, at a volume of 0. 1 ml on a half inch square of surgical gauze, to the clipped inter-scapular region of the guinea-pigs in each group. The gauze was covered with impervious adhesive tape. The dressings were left in place for 24 hours. The test animals were challenged two weeks after the epidermal induction application. None of the test animals exhibited a dermal reaction to the challenge application of the test materials. Based on these results, the test material is not considered to be a skin sensitizer in guinea pigs.
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