Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-842-9 | CAS number: 7758-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Copper Monochloride CAS No: 7758-89-6, Final 10/2006
- Author:
- OECD SIDS
- Year:
- 2 006
- Reference Type:
- other: Study cited in OECD SIDS
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- other: Mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Copper chloride
- EC Number:
- 231-842-9
- EC Name:
- Copper chloride
- Cas Number:
- 7758-89-6
- Molecular formula:
- Cl Cu
- IUPAC Name:
- λ¹-copper(1+) chloride
- Details on test material:
- - Name of test material (as cited in study report): Copper monochloride (CuCl),
- Analytical purity: purity 99%
- Lot/batch No.: Sigma-Aldrich corporation, LOT No. 17119BO
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 8 weeks
- Weight at study initiation: no data
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Route of administration:
- other: negative control: oral gavage; positive control: intraperitoneal injection
- Vehicle:
- - Vehicle(s)/solvent(s) used: 0.5 % CMC (carboxymethyl cellulose);
- Lot/batch no. (if required): LOT No.-32K0007 - Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
- no data
DIET PREPARATION
- no data - Duration of treatment / exposure:
- single exposure
- Frequency of treatment:
- duplicate treatments (only positive control group was dosed once)
- Post exposure period:
- 24 h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Three dose levels, 15, 30 and 60 mg/kg bw/day, were determined for the micronucleus experiment based on the results of dose range finding experiment
Basis:
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- mitomycin C;
- Route of administration: intraperitoneal injection
- Doses / concentrations: 2.0 mg/kg of Mitomycin C
Examinations
- Tissues and cell types examined:
- polychromatic erythrocytes
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION:
dose range finding experiment
- Evaluation criteria:
- at least 1,000 polychromatic erythrocytes per animals were scored for the incidence of micronuclei.
- Statistics:
- Chi-square test (using a 2 × 2 contingency table)
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
Any other information on results incl. tables
All animals dosed with copper monochloride exhibited similar PCE/(PCE + NCE) ratios and MNPCE frequencies compared to those of negative control animals. All frequencies of MNPCE in the negative control groups fell
within acceptable ranges, while the positive control groups induced clear increase in the frequencies of MNPCE.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.