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EC number: 308-072-8 | CAS number: 97862-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD 105, good documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction product of C18 unsatd. fatty acid diethanolamide and maleic anhydride, sulphonated, sodium salt
- IUPAC Name:
- Reaction product of C18 unsatd. fatty acid diethanolamide and maleic anhydride, sulphonated, sodium salt
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Butanedioic acid, sulfo-, 4-[2-[(2-hydroxyethyl)amino]ethyl] ester, N-C18-unsatd. acyl derivs., disodium salts
Lot/Batch number: FL21-22-RS
CAS number: 97862-28-7
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- n-octanol
- Solubility:
- 47.8 other: percent
- Temp.:
- 20 °C
- Remarks on result:
- other: The more hydrophilic constituents of the test item, which elute first, were almost insoluble in n-octanol. The more hydrophobic constituents, which eluted later from the column, were in contrast soluble.
- Test substance stable:
- yes
Any other information on results incl. tables
Table 1 results
Experiment |
Nominal saturation concentration (g/L) |
n-Octanol solubility, Results (g/L) |
Recovery (% of nominal) |
1 |
0.45 |
0.25 |
56% |
0.75 |
0.39 |
52% |
|
1.5 |
0.7 |
47% |
|
2 |
7.5 |
3.6 |
48% |
10 |
4.1 |
41% |
|
15 |
7.9 |
53% |
|
25 |
10.4 |
42% |
|
3 |
780 |
355 |
46% |
The results of the n-octanol solubility given in the table above show that no concentration plateau is achieved. Hence, the n-octanol solubility does not dependent on the nominal saturation concentration.
The comparison of the chromatograms of the calibration solution and test solution showes, that the more hydrophilic constituents of the test item, which elute first, are almost unsoluble in n-octanol. The more hydrophobic constituents, which elute later from the column, are in contrast soluble.
The n-Octanol solubility of Butanedioic acid, sulfo-, 4-[2-[(2-hydroxyethyl)amino]ethyl] ester, N-C18-unsatd. acyl derivs., disodium salts is dependent on the nominal concentration which was weighed. In the arithmetic mean 47.8 % of the nominal concentration is solved in n- Octanol. The standard deviation is about 5%.
The n-Octanol solubility was determined at 20 °C. pH value cannot be indicated, as pH is only defined for aqueous solutions, not for octanol solutions.
Applicant's summary and conclusion
- Executive summary:
In the non-GLP Klimisch 1 study from Frischmann (2012) the octanol solubility of Butanedioic acid, sulfo-, 4-[2-[(2-hydroxyethyl)amino]ethyl] ester, N-C18-unsatd. acyl derivs., disodium salts was determined following the method as outlined in the OECD 105. Instead of water, octanol was used.
The results of the n-octanol solubility that no concentration plateau is achieved within the nominal concentration range of 0.45 to 780 mg/L. The octanol solubility at 20°C was determined to be 47.8% at nominal concentrations ranging from 0.45 to 780 mg/L. The comparison between the chromatograms of the calibration solutions and test solutions showed, that the more hydrophilic constituents of the test item, which elute first, were almost insoluble in n-octanol. The more hydrophobic constituents, which eluted later from the column, were in contrast soluble.
Therefore, the n-Octanol solubility of Butanedioic acid, sulfo-, 4-[2-[(2-hydroxyethyl)amino]ethyl] ester, N-C18-unsatd. acyl derivs., disodium salts is proportional to the nominal concentration in the range from 0.45 to 780 g/L. In the arithmetic mean 47.8 % of the nominal concentration is solved in n- Octanol.
This value is considered relevant an reliable for the risk assessment.
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