Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-254-8 | CAS number: 10101-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 July - 11 October 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Cobalt wolframate
- EC Number:
- 233-254-8
- EC Name:
- Cobalt wolframate
- Cas Number:
- 10101-58-3
- Molecular formula:
- CoO4W
- IUPAC Name:
- cobalt wolframate
- Details on test material:
- Name: "COBALT WOLFRAMATE".
Trade name: Cobalt wolframate.
Chemical name: Cobalt wolframate.
Molecular formula: CoWO4.
Batch No.: 750702_20100329.
CAS No.: 10101-58-3.
Appearance: Fine grained dark-blue powder.
Purity: > 98%
Impurity: WO3 < 2 %
Solubility: Not soluble in water.
Conditions of storage: Room temperature.
Stability at conditions of storage: Stable.
Expiry date: 31 May 2015.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Species, strain: Rats, Crl:CD(SD).
Supplier: Charles River Deutschland GmbH, D-97633 Sulzfeld.
Number and sex: 12 females.
Age: Between 8 and 12 weeks at the time of the administration.
Health conditions: A health inspection was performed prior to the commencement of treatment to ensure that the animals were in a good state of health.
Hygiene: Optimal hygienic conditions.
Room number: EH1-23.
Room temperature: Mean of 20.70 °C (continuous control and recording).
Relative humidity: Mean of 56.22 % (continuous control and recording).
Air exchange: 12 per hour.
Light: Artificial light from 6 a.m. to 6 p.m.
Cages: Single caging in Makrolon cages type III (37.5 cm x 21.5 cm bottom area, 18 cm height). Wire mesh lids. Sanitation of cages once a week.
Bedding material: Aspen wood chips, Fa. ABEDD Dominik Mayr KEG, A-8580 Köflach, autoclaved. Random samples of the bedding material are analysed for contaminants by the supplier. Changes 1 / week.
Environmental enrichment: Nibbling wood bricks (10 cm x 2 cm x 2 cm) and nesting material, both from the same material and source as the bedding material, were offered to the animals once a week.
Feed: Ssniff R/M-H maintenance diet for rats and mice (item V1534-300) ad libitum, supplied by Ssniff Spezialdiäten GmbH, 59494 Soest, Germany. Analysis of the feed for ingredients and contaminants is performed randomly by Ssniff.
Exception: The feed was withdrawn the evening before the administration of the test substance and was offered again about three hours afterwards.
Water: Tap water from an automatic watering system, ad libitum. Random samples of the water are analysed by the "AGES",
A-1226 Vienna, to check, if the water fulfils the requirements for drinking water for humans.
Identification: Labelling with felt-tipped pen on the tail and on the cage.
Acclimatisation: At least 7 days.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- deionised
- Details on oral exposure:
- Deionised water was used as vehicle for the test substance.
Justification: A homogeneous suspension could be prepared with water and water shall be used preferably, according to the guidelines.
The test substance was administered as a suspension.
The suspensions were prepared freshly before administration and were administered within 15 minutes after the preparation.
A peroral administration was performed once in the morning by stomach intubation using a metal gavage.
The dose volume was 10 mL per kg body weight. The individual dose volumes were calculated using the body weights determined on the day of the administration.
Test procedure
Annex 2c of the OECD guideline and Annex 1c of the EC-Directive were used for the stepwise dosing to groups of 3 females each.
The sequence of dosing of the test substance was:
• Step 1: 300 mg per kg body weight.
• Step 2: 300 mg per kg body weight.
• Step 3: 2000 mg per kg body weight.
• Step 4: 2000 mg per kg body weight.
Justification for the selection of the dose
As no prior information on the toxicity of the test substance was available, a starting dose of 300 mg of the test substance per kg body weight was chosen. The further proceeding was in accordance with the guideline/directive. - Doses:
- 300 and 2000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Clinical observations
Observations were performed within the periods 0 - 0.5, 0.5 - 1, 1 - 2, 2 - 4 and 4 - 6 hours after administration (p.a.) of the test substance and then at least once a day for a total of 2 weeks. Observations included but were not limited to changes in skin, fur, eyes, the occurrence of secretions and excretions, autonomic activity, changes in gait, posture and the presence of convulsions.
Body weights and body weight gain
Body weights were determined
• before administration.
• 7 days p.a.
• 14 days p.a.
Body weight gain was calculated for each week of the study, i.e. between
• 0 and 7 days p.a.
• 7 and 14 days p.a.
The animals were sacrificed by inhalation of 80 % CO2 + 20 % air 14 days p.a. and subjected to a necropsy including a gross pathological examination. - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived until the scheduled termination of the study.
- Clinical signs:
- other: All animals did not show any clinical signs during the entire observation period.
- Gross pathology:
- No abnormal findings were made in all animals at the necropsy 14 d p.a.
- Other findings:
- None
Any other information on results incl. tables
Synopsis of the results
Dose |
Step No. |
Animal |
Number of animals |
||
(mg/kg) |
|
Nos. |
exposed |
affected |
deceased |
300 |
1 |
11, 12, 13 |
3 |
0 |
0 |
300 |
2 |
14, 15, 16 |
3 |
0 |
0 |
2000 |
3 |
21, 22, 23 |
3 |
0 |
0 |
2000 |
4 |
24, 25, 26 |
3 |
0 |
0 |
Body weights and body weight gain
Individual data, means and standard deviations SD.
Dose |
Animal |
Body weight (g) |
Body weight gain (g) |
||||
mg/kg (Step No.) |
No. |
before |
7 days |
14 days |
death |
0-7 days |
7-14 days |
300 |
11 |
182 |
219 |
231 |
- |
37 |
12 |
(1) |
12 |
189 |
229 |
247 |
- |
40 |
18 |
|
13 |
193 |
219 |
221 |
- |
26 |
2 |
|
mean |
188.0 |
222.3 |
233.0 |
- |
34.3 |
10.7 |
|
SD |
5.6 |
5.8 |
13.1 |
- |
7.4 |
8.1 |
300 |
14 |
220 |
261 |
280 |
- |
41 |
19 |
(2) |
15 |
197 |
232 |
257 |
- |
35 |
25 |
|
16 |
194 |
236 |
240 |
- |
42 |
4 |
|
mean |
203.7 |
243.0 |
259.0 |
- |
39.3 |
16.0 |
|
SD |
14.2 |
15.7 |
20.1 |
- |
3.8 |
10.8 |
2000 |
21 |
179 |
215 |
231 |
- |
36 |
16 |
(3) |
22 |
177 |
214 |
230 |
- |
37 |
16 |
|
23 |
175 |
215 |
241 |
- |
40 |
26 |
|
mean |
177.0 |
214.7 |
234.0 |
- |
37.7 |
19.3 |
|
SD |
2.0 |
0.6 |
6.1 |
- |
2.1 |
5.8 |
2000 |
24 |
196 |
221 |
223 |
- |
25 |
2 |
(4) |
25 |
185 |
205 |
224 |
- |
20 |
19 |
|
26 |
191 |
222 |
235 |
- |
31 |
13 |
|
mean |
190.7 |
216.0 |
227.3 |
- |
25.3 |
11.3 |
|
SD |
5.5 |
9.5 |
6.7 |
- |
5.5 |
8.6 |
Observations in life
Findings |
Dose |
Animal Nos. |
Observation time |
no clinical signs |
300, 1 |
11, 12, 13 |
0 h / 14 d |
|
300, 2 |
14, 15, 16 |
0 h / 14 d |
|
2000, 3 |
21, 22, 23 |
0 h / 14 d |
|
2000, 4 |
24, 25, 26 |
0 h / 14 d |
Necropsy findings
Number of animals examined: 12 females.
SYSTEM |
Dose |
Step No. |
Animal Nos. |
no abnormal findings |
300 |
1 |
11, 12, 13 |
|
300 |
2 |
14, 15, 16 |
|
2000 |
3 |
21, 22, 23 |
|
2000 |
4 |
24, 25, 26 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No toxic effects of the test substance were noted by signs in life and post mortem at a dose of 2000 mg test substance per kg body weight. No mortality occurred.
According to Commission Directive 2001/59/EC "COBALT WOLFRAMATE" does not require classification for acute oral toxicity. - Executive summary:
The aim of the study was to investigate acute toxic effects of the test substance after a single peroral administration to rats.
Methods
Methods and investigations were performed in conformance with the OECD-Guideline 423, 17 December 2001 and theCouncil Regulation (EC) No 440/2008,Method B.1 tris.
Administration of the test substance
"COBALT WOLFRAMATE"was administered once orally via gavage as a suspension in deionised water to female Crl:CD(SD) rats.
The dosing was performed sequentially to groups of 3 animals per step using a starting dose of 300 mg per kg body weight and 2000 mg per kg body weight as the second dose.
The dose volume was 10 mL per kg body weight for all groups.
Investigations
· Body weights: before administration, 7 and 14 days after the administration (p.a.).
· Clinical observations: at least once per day.
Necropsy: The animals were sacrificed and necropsied 14 days p.a.Results
Dose
(mg/kg)Step No.
No. of animals
Prominent findings
exposed
affected
deceased
in life
post mortem
300
1
3
0
0
none
none
300
2
3
0
0
none
none
2000
3
3
0
0
none
none
2000
4
3
0
0
none
none
Presence of signs in life
no signs
Full recovery of the animals
not applicable
Body weights
all animals gained weight in both weeks p.a.
Findings in life and post mortem indicate
no toxic effects present
LD50, oralaccording to OECD
> 5000 mg/kg body weight
Conclusion
According to Commission Directive 2001/59/EC"COBALTWOLFRAMATE"does not require classification for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.