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EC number: 500-425-6 | CAS number: 159034-91-0 1 - 6.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August-September 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective was to investigate the degree of irritation produced to the abraded and intact skin of 6 albino rabbits following 24 hours occluded contact with the test material. The procedure used is that described in the US Federal Register 1973, Vol.38, No.187, Section 1500:41.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with diethylamine
- EC Number:
- 500-425-6
- EC Name:
- Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with diethylamine
- Cas Number:
- 159034-91-0
- Molecular formula:
- Not available for this UVCB
- IUPAC Name:
- Reaction product of poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-[(1-oxo-2-propenyl)oxy]-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1) and N-ethylethanamine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS = Healthy females
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: in grid bottomed galvanised metal cages.
- Diet (e.g. ad libitum): 90-95g of a commercially available pelleted rabbit diet were provided for each animal at a similar time each day.
- Water (e.g. ad libitum): An automatic watering system provided a constant summply of drinking water to the cages.
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no details, but air-conditionned-room
- Photoperiod (hrs dark / hrs light): 10h/14h
Test system
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- No preparation of the supplied material was necessary.
0.5 ml of the test material was applied to each of two 2.5 cm square surgical lint pads attached to "sleek" plastic adhesive wrapping. The lint suares were then placed in contact with the animal's skin, one lint square in contact with abraded skin and one lint square with intact skin, bilateral to the midline, and secure in position by the attached "Sleek" adhesive tape. The entire trunk of the animal was then encircled with a length of elastic adhesive bandage 7.5 cm wide. - Duration of treatment / exposure:
- 24h
- Observation period:
- The reaction sites were assessed at 1 hour and at 48 hours after patch removal.
- Number of animals:
- 6
- Details on study design:
- At least one hour before dosing the rabbits were placed in restraining stocks and the dorsal surface of the rabbits closely clipped ove an area consisting of approximately 10% of the total surface area, using an Oster model A.2 clipper with Angra blade.
The left flank was then lightly abraded with the point of 25 x 0.6 mm sterila disposable hypodermic needle. The abrasions were sufficiently deep to damage the stratum corneum but not to penetrate the dermis. the skin of the right flank remainded intact.
After a contact period of 24 hours the adhesive tapes and lint patches were removed from the animals. One hour was then allowed to permit irritation from the adhesive tapes to subsade then the reaction sites were assessed using the scoring system of Draize.
The values obtained for erythema at both abraded and intact sites at the 24 and 72 hour readings were summed and the total divided by six, the number of rabbits, to give an average score for erythema. The values obtained for oedema were treated in a similar manner to give an average score for aedema. A primary irritation score was calculated by adding the total value obtained for erythema to tje total of value obsained for oedema dividing by six to give an average of the total score. This average was then divided by four to give a value referred to as the primary irritation score.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 1.08
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin / Individual scores = 2 - 1 - 0.5 - 0.5 - 0.5 - 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Intact skin / individual scores = 1 - 0 - 0 - 0 - 0 - 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin / Individual scores = 2 - 1 - 1 - 0.5 - 1.5 - 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Abraded skin / Individual scores = 1 - 0.5 - 0 - 0 - 0.5 - 2
- Irritant / corrosive response data:
- The average scores produced by the group of 6 rabbits were 4.8 for erythema and 2.3 for oedema, giving a primary irritation score of 1.8.
No data on reversibility of effects are showed. - Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- not skin irritating
- Conclusions:
- According to this study, Diethylamine modified ethoxylated trimethylolpropane triacrylate is considered as slightly irritant but it is not classified as skin irritant according to CLP criteria.
- Executive summary:
The objective of this study was to investigate the degree of irritation produced to the abraded and intact skin of 6 albino rabbits following 24 hours occluded contact with Diethylamine modified ethoxylated trimethylolpropane triacrylate.
Erythema and/or oedema were observed in all animals exposed to the substance (intact and abraded skin). However the effect are not severe, each score is equal or smaller than 2 (out of 4).
Diethylamine modified ethoxylated trimethylolpropane triacrylate is considered as slightly irritant but it is not classified as irritant according to CLP criteria.
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