Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 908-531-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- For this endpoint, an analysis based on the components is performed. Based on SIDS report on Sodium carbonate and sodium hydroxide, no repeated toxicity has to be taken into account whatever the route of administration. A NOAEC has been derived for Na2S, on its registration dossier, based on a 90 days inhalation studies on two rat strains and mice (Dorman et al, 2004, Respiratory tract toxicity of inhaled hydrogen sulphide in fischer-344 rats, Sprague-Dawley rats and B6C3F1 mice following subchronic (90 day) exposure). Based on this study the NOAEC considered for the multi-constituent is derived from the sulphide registration dossier: 80 ppm (410 mg/m3).
Data source
Reference
- Reference Type:
- publication
- Title:
- Respiratory tract toxicity of inhaled hydrogen sulphide in fischer-344 rats, Sprague-Dawley rats and B6C3F1 mice following subchronic (90 day) exposure
- Author:
- Dorman et al
- Year:
- 2 004
- Bibliographic source:
- Toxicology and Applied Pharmacology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: No guideline follow
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
Constituent 1
Administration / exposure
- Route of administration:
- inhalation: vapour
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 80 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no relevant alterations in haematological indices, serum chemistries or gross pathology
Target system / organ toxicity
- Critical effects observed:
- no
- Lowest effective dose / conc.:
- 80 ppm
- System:
- respiratory system: upper respiratory tract
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
Any other information on results incl. tables
The 80 ppm correspond to approximatively 410 mg/m3 of sodium sulfide
Applicant's summary and conclusion
- Conclusions:
- The NOAEC used and estimated for the multi-constituent is equal to 80 ppm (equivalent to approximately 410 mg/m3)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.