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EC number: 617-351-6 | CAS number: 82544-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - Apr 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5,6 beta-Epoxy-7 beta-hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androstan-17-one
- EC Number:
- 617-351-6
- Cas Number:
- 82544-13-6
- Molecular formula:
- C25 H36 O5
- IUPAC Name:
- 5,6 beta-Epoxy-7 beta-hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androstan-17-one
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): municipal sewage treatment plant ("Kläranlage Berlin-Ruhleben")
- Laboratory culture: Schering AG, Ecotoxicology
- Storage conditions: room temperature - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
TEST SYSTEM
- Culturing apparatus:
- Details of trap for CO2 and volatile organics if used: For the determination of the CO2 produced, three CO2-absorber bottles, filled with 100 mL 0.025 N Ba(OH) each, were connected in series to the exit air-pipe of each test bottle. The amount of CO2 produced was determined by titration of the remaining Ba(OH)2 with 0.05 N standardized HCI. On days 4, 7, 11, 16, 21, 25 and 30 the CO2-absorber bottle nearest to the test bottles was removed for the titration, with the exception of day 30 when all three bottles were removed. The remaining two absorbers were each moved one place closer to the test vessel and a new absorber bottle filled with fresh Ba(OH)2 was placed at the far end of the series.
SAMPLING
- Sampling frequency: sampled on day 4, 7, 11, 16, 21, 25 and 30. On day 29 the solutions were acidified in order to expel all dissolved CO2, and CO2 was determined on day 30.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 3 vessels
- Abiotic sterile control: no
- Toxicity control: yes, 1 vessel
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 30 d
- Details on results:
- The test compound ZK 90346 was not degraded by day 30 (28 days of incubation).
BOD5 / COD results
- Results with reference substance:
- The reference substance was degraded to 90.8% after 30 d.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- In accordance with the OECD guideline the test compound ZK 90346 is not readily
biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge. - Executive summary:
The purpose of this study was to determine the ready biodegradability of Methylenepoxidpivalat (ZK 90346), an intermediate of the synthesis of drospirenone. The study was conducted in agreement with the test guideline OECD 301 B, Ready biodegradability: C02-evolution test, adopted Jul. 92, OECD Paris, 93.
The test substance ZK 90346 was incubated in a concentration of 10 mg carbon/L in an aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days.
The test compound ZK 90346 was not degraded by day 30 (28 days of incubation). The reference compound sodium acetate was degraded to 83% on day 30 (28 days of incubation).
In the toxicity contral, the reference compound (sodium acetate) plus the test compound ZK 90346 was degraded up to 41 % on day 30 (28 days of incubation), thus reflecting the degradation of the substances incubated separately.
Accordingly, the test compound ZK 90346 is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge.
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