Registration Dossier
Registration Dossier
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EC number: 209-025-3 | CAS number: 552-89-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
TEST SYSTEM: AMES SALMONELLA TYPHIMURIUM
STRAIN INDICATOR: TA98, TA100, TA1535, TA1537, TA1538
METABOLIC ACTIVATION: NONE
METHOD: PREINCUBATION
DOSE: 0.01-5 MG/PLATE (TEST MATERIAL SOLVENT: DMSO)
RESULTS: NEGATIVE
STRAIN INDICATOR: TA98, TA100, TA1535, TA1537, TA1538
METABOLIC ACTIVATION: RAT, LIVER, S-9, POLYCHLORINATED BIPHENYL
METHOD: PREINCUBATION
DOSE: 0.01-5 MG/PLATE (TEST MATERIAL SOLVENT: DMSO)
RESULTS: NEGATIVE
TEST SYSTEM: AMES SALMONELLA TYPHIMURIUM
STRAIN INDICATOR: TA98, TA100
METABOLIC ACTIVATION: NONE
METHOD: PREINCUBATION
RESULTS: NEGATIVE
STRAIN INDICATOR: TA98, TA100
METABOLIC ACTIVATION: RAT, LIVER, S-9, KANECHLOR 500
METHOD: PREINCUBATION
RESULTS: NEGATIVE
TEST SYSTEM: AMES SALMONELLA TYPHIMURIUM
STRAIN INDICATOR: TA98, TA100, TA1535, TA1537, TA1538
METABOLIC ACTIVATION: NONE
METHOD: STANDARD PLATE
DOSE: 33-3333 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
RESULTS: NEGATIVE
STRAIN INDICATOR: TA98, TA100, TA1535, TA1537, TA1538
METABOLIC ACTIVATION: RAT, LIVER, S-9, AROCLOR 1254
METHOD: STANDARD PLATE
DOSE: 33-3333 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
RESULTS: NEGATIVE
STRAIN INDICATOR: TA98, TA100, TA1535, TA1537, TA1538
METABOLIC ACTIVATION: HAMSTER, LIVER, S-9, AROCLOR 1254
METHOD: STANDARD PLATE
DOSE: 33-3333 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)
RESULTS: NEGATIVE
MUTAGENICITY STUDIES: TEST SYSTEM: Mouse lymphoma
STRAIN INDICATOR: L5178Y (tk+/tk-)
METABOLIC ACTIVATION: None
METHOD: Suspension/plate
DOSE: 30-150 ug/ml
RESULTS: Negative
TEST SYSTEM: Mouse lymphoma
STRAIN INDICATOR: L5178Y (tk+/tk-)
METABOLIC ACTIVATION: Rat, Liver, S-9, Aroclor 1254
METHOD: Suspension/plate
DOSE: 30-150 ug/ml
RESULTS: Negative
Short description of key information:
The information was generated from the Chemical Carcinogenesis Research Information System (CCRIS), a database of the National Library of Medicine's TOXNET system (http://toxnet.nlm.nih.gov) on January 17, 2014.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The mutagenicity potential of the substance was evaluated with Ames tests and Mouse lymphoma test.
The result of the reported studies was NEGATIVE, both for the Ames test that for the Mouse lymphoma test .
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