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Diss Factsheets
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EC number: 205-187-4 | CAS number: 135-37-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with column 2 of REACH Annex IX, the effects on soil microorganisms study does not need to be conducted as direct and indirect exposure of the soil compartment is unlikely. The substance shows a low adsorptive (worst case log Koc = 1) as well as a bioaccumulative (log Kow = -8.27) potential. Hence, a relevant distribution into soil and a considerable exposure of soil microorganisms is not expected.
Key value for chemical safety assessment
Additional information
In Annex X of Regulation (EC) No 1907/2006, it is stated that long-term toxicity to terrestrial organisms shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects of the substance and/or relevant degradation products on terrestrial organisms. Column 2 of Annex X states that studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely. There are no ecotoxicity studies for terrestrial organisms relating to EDG and the requirement for terrestrial data is waived based on the low adsorption, low bioaccumulation potential, very low toxicity to aquatic organisms (extrapolated to terrestrial organisms), ready biodegradability and unlikely exposure to EDG in soil.
Adsorption
It is not expected that EDG will adsorb onto the organic fraction of soils, sediments or suspended solids due to the ionic structure of the substance. The worst-case calculated log Koc for this substance is 1 (see IUCLID section 5.4.1, Mensink, 2013). However, interaction with the mineral phase may be possible. This assumption is supported by the studies with the structurally comparable NTA conducted by Dunlapet al.,(1971) andBolton et al.,(1993) who demonstrated that Na3NTA is neither strongly adsorbed by loam, clay-loam and sandy soils or marine surface sediments (Kp sediment-water = 1.6 L/kg). In addition, EDG and Na3NTA are highly water-soluble organic substances.
Bioaccumulation
The partitioning behaviour of EDG was estimated using the EPIWIN4.1 model (see IUCLID section 4.7, Mensink 2013). The log Kow was calculated to be -8.27, indicating limited potential for bioaccumulation.
In addition, it was determined that the partitioning behaviour of the structurally comparable Na3NTA is pH-dependent and the estimated Log Kow for the different NTA species is highest at pH 1.4, with a value of -4.14; at pH 7, the log Kow reduces to -13.2. At pH 14, the estimated log Kow is -31.2. The substance’s high hydrophilicity is demonstrated by the very low log octanol-water partition coefficient (Log Kow) of -13.2 at a neutral pH. These low distribution coefficients and Log Kow indicate these substances have a low adsorptive and bioaccumulative potential.
Biodegradability
The substance is regarded as readily biodegradable (see IUCLID section 5.2).
In addition, the Canadian Ministry of the Environment (CCME, 2010) provides additional evidence of the rapid degradation of NTA and products where it was reported that NTA is readily biodegraded in all environmental compartments even at low environmental temperatures. Therefore, biodegradation can be considered to be an important removal process in soil, sediment, surface water, and water treatment plants.
There are no identified uses of the substance which involve direct application to soil. Indirect exposure of soil organisms, for example via sewage sludge disposal to land or release of residual quantities of dilute EDG to sediment, is unlikely as the substance is readily biodegradable and has a very low sorption potential.
Toxicity
Furthermore, it is reasonable to assume that trends seen in aquatic toxicity are likely to be observed in terrestrial organisms. Reliable toxicity data are available for freshwater species representing fish, invertebrates, algae and a mollusc. Short-term (acute) exposures of EDG and Na3NTA showed values generally > 100 mg/L. All trophic levels of aquatic organisms revealed similar sensitivities to EDG and Na3NTA. Long-term exposures to invertebrates and fish revealed NOECs of 7.5 and >43 mg/L, respectively based on the values from Na3NTA. For EDG a NOEC for algae was concluded at 12 mg/L. These short- and long-term data, when considered with bioaccumulative and degradation information, result in EDG being non-classified and considered to be practically non-toxic to aquatic organisms. It is reasonable to assume that EDG will also be non-toxic to soil organisms.
Exposure
There are no identified uses of the substance which involve direct application to soil. Moreover, due to the high solubility, ready biodegradability and low octanol-water partition coefficient of EDG, this substance will not sorb to or persist in aerobic soil when used as directed under environmental conditions.
In summary, based on the evidence of low adsorption, low bioaccumulative potential, very low toxicity to aquatic organisms (extrapolated to soil organisms) and ready biodegradability,the requirement for terrestrial data is waived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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