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EC number: 270-752-4 | CAS number: 68477-71-4 A complex combination of hydrocarbons obtained from fractionation of catalytic cracked gas oil hydrocarbon stream and treated to remove hydrogen sulfide and other acidic components. It consists of hydrocarbons having carbon numbers in the range of C3 through C5, predominantly C4.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: For this endpoint, GLP compliant guideline animal experimental study, published in peer reviewed literature, fully adequate for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Remarks:
- Exposures and micronucleus test to GLP
- Type of assay:
- micronucleus assay
Test material
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: gas
- Duration of treatment / exposure:
- Up to 20 days
- Frequency of treatment:
- 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 200, 2000 and 10,000 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 8
- Control animals:
- yes
- Positive control(s):
- - A 2 mg/mL solution of CP (in Milli-Q water) was prepared immediately prior to dosing. CP was administered to eight male rats (MN-positive control) by a single oral intubation using a dose volume of 10 mL/kg, yielding a dosage of 20 mg/kg.
- On inhalation exposure day 19, a separate group of eight untreated, male rats (Hprt-positive control) received a single oral intubation of the positive control agent CP (20 mg/kg in water).
Examinations
- Statistics:
- Statistics were calculated on exposure concentration and environmental conditions data and CE determinations. The individual rat was generally the experimental unit of analysis. Body weight and cell proliferation (expressed as ULLI) data were tested for lack of trend, and if not significant, then sequential application of the Jonckheere-Terpstra trend test or one-way ANOVA followed with Dunnett's test was performed. Results were statistically analysed for significance using the Pearson product-moment correlation for CE data and the Mann-Whitney rank sum test for Hprt mutation frequency data.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
No propene-related statistically significant changes in mean bodyweights or mean bodyweight gain was observed in any exposure group. No statistically significant differences in food consumption or food efficiency were observed in any exposure group. No mortality or clinical signs of toxicity were observed in any dose group during the study.
No effects on micronuclei frequencies were observed in the bone marrow at any exposure level. No toxic effects in rat bone marrow cells (decreased polychromatic/normochromatic ratio) were observed at any exposure level. The positive control, cyclophosphamide, induced a significant increase in the frequency of micronucleated PCEs (p 0.05 by Dunn's test). However, no toxic effects in the bone marrow cells were observed.
Micronucleus evaluation of rats (F344, male) following 20-day exposure to propene by inhalation
(Table based on Pottenger et al, Toxicological Sciences 97(2), 336-347 (2007), Table 5)
|
Propene concentration in air 0 ppm |
Propene concentration in air 200ppm |
Propene concentration in air 2000ppm |
Propene concentration in air 10000ppm |
Positive control: 20 mg/kg CP |
Micronucleated poly-chromatic erythrocytes /2000 PCEs |
1.8±1.3 |
2.5±1.9 |
2.3±1.6 |
1.1±1.1 |
15.0±6.0* |
PCE/NCE ratio |
0.577±0.155 |
0.573±0.267 |
0.749±0.290 |
0.692±0.211 |
0.715±0.437 |
PCE/NCE ratio = mean of the PCE/NCE for the individual animals per 1000 erythrocytes scored *Stat sig p<0.05 by Dunn’s test |
Applicant's summary and conclusion
- Conclusions:
- Propene did not induce a statistically significant increase in micronucleated polychromatic erythrocytes in rat bone marrow when evaluated after a total of 20 exposures. The highest exposure level was 10,000 ppm. Therefore, the test substance was negative in this in vivo assay.
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