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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-610-8 | CAS number: 31394-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment. Vapour generation and analysis not well documented.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- specific investigations: other studies
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment. Vapour generation and analysis not well documented.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Details on results:
- Large increases in respiration were noted in the animals during both exposure periods. No classic alteration in breathing patterns that would be indicative of upper airway irritation was noted in any of the animals.
- Conclusions:
- Based on these results, exposure to Isooctane at a nominal concentration of 33.52 mg/L of air did elicit an apparent response from the animals upon exposure, however, it did not appear to produce upper airway irritancy in the mice.
- Executive summary:
This data is being read across from the source study that tested 2,2,4-trimethylpentane (isooctane) based on analogue read across.
Based on these results, exposure to Isooctane at a nominal concentration of 33.52 mg/L of air did elicit an apparent response from the animals upon exposure, however, it did not appear to produce upper airway irritancy in the mice.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Respiratory tract irritancy determined by measuring the degree of sensory irritation.
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- 2,2,4-trimethylpentane
- EC Number:
- 208-759-1
- EC Name:
- 2,2,4-trimethylpentane
- Cas Number:
- 540-84-1
- Molecular formula:
- C8H18
- IUPAC Name:
- 2,2,4-trimethylpentane
- Details on test material:
- - Name of test material (as cited in study report): Isooctane
- Analytical purity: 100% pure commercial product
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: head only exposure chamber
- Source and rate of air: room air - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 2 treatments of 1 minute with 10 minute non-treatment period between each treatment.
- Frequency of treatment:
- once
- Post exposure period:
- none
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
99.54 mg/L (corresponding to 21000 ppm)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
33.52 mg/L
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 males
- Control animals:
- other: each animal established control breathing pattern prior to treatment by exposure to room air
Results and discussion
- Details on results:
- Large increases in respiration were noted in the animals during both exposure periods. No classic alteration in breathing patterns that would be indicative of upper airway irritation was noted in any of the animals.
Applicant's summary and conclusion
- Conclusions:
- Based on these results, exposure to Isooctane at a nominal concentration of 33.52 mg/L of air did elicit an apparent response from the animals upon exposure, however, it did not appear to produce upper airway irritancy in the mice.
- Executive summary:
Based on these results, exposure to Isooctane at a nominal concentration of 33.52 mg/L of air did elicit an apparent response from the animals upon exposure, however, it did not appear to produce upper airway irritancy in the mice.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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