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EC number: 259-701-7 | CAS number: 55542-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Dec 2000 to Mar 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well reported GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one
- EC Number:
- 259-701-7
- EC Name:
- 17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one
- Cas Number:
- 55542-27-3
- Molecular formula:
- C22H34O3
- IUPAC Name:
- 17 beta-Hydroxy-17 alpha-(3-hydroxypropyl)-4-androsten-3-one
- Details on test material:
- - Name of test material (as cited in study report): ZK 57797
- Batch No.: 59012052, white powder
- Purity: approx. 91.2% (DC)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% (m/v) solution of Tylose MH 1000 in distilled water
- Doses:
- 2000 mg/kg (3 male and 3 females) and 200 mg/kg (3 females)
- No. of animals per sex per dose:
- 3 (at 200 mg/kg only 3 females)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
One female animal of the 2000 mg/kg dose group died one day after administration. None of the male animals and of the female animals of the 200 mg/kg dose group died. Strong clinical signs were observed only in female animals of the 2000 mg/kg dose group (rough hair coat, squatting abdominal or lateral position, apathy, coma) shortly after administration until three days after administration. None of the male animals and of the female animals of the 200 mg/kg dose group showed alterations of the general state of well-being. The strong difference between male and female animals is very conspicuous. The body weight gain was not affected in the surviving animals with exception of one female animal of the high dose group. In this case it was normal during the first week but decreased in the second week. Only in the died female animal macroscopic pathological findings (stomach content grey and thin-mushy, small intestine mucous membrane partial haemorrhagic, lung haemorrhagic infarcted) were observed. Macroscopic pathological findings were not observed in the surviving animals.
Applicant's summary and conclusion
- Executive summary:
The single oral administration of the test substance (ZK 57797) to male and female rats at a dose of 2000 mg/kg and to female rats at a dose of 200 mg/kg led to death of one female animal of the 2000 mg/kg dose group died. All other treated animals survived the 14 day observation period. Strong clinical signs were observed only in female animals of the 2000 mg/kg dose group (rough hair coat, squatting abdominal or lateral position, apathy, coma) shortly after administration until three days after administration. None of the male animals and of the female animals of the 200 mg/kg dose group showed alterations of the general state of well-being. The body weight gain was not affected in the surviving animals with exception of one female animal of the high dose group. In this case it was normal during the first week but decreased in the second week. Only the died female animal showed macroscopic pathological findings (stomach content grey and thin-mushy, small intestine mucous membrane partial haemorrhagic, lung haemorrhagic infarcted).
The acute oral toxicity of Hydroxypropyltesto in rats is above 2000 mg/kg body weight.
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