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Diss Factsheets
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EC number: 265-088-7 | CAS number: 64741-86-2 A complex combination of hydrocarbons obtained by subjecting a petroleum distillate to a sweetening process to convert mercaptans or to remove acidic impurities. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 150°C to 345°C (302°F to 653°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-01-07 to 1982-01-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study report is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- The temperature of the animal room ranged from 68.0 to 73.4 degrees Fahrenheit and the relative humidity ranged from 32 to 64%.
- Principles of method if other than guideline:
- Dosed 5 male and 5 female Sprague-Dawley rats with single dose of test material through gavage. Monitored the animals for 14 days after which gross necropsy was performed.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- American Petroleum Institute Medicine and Biological Science Department
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- IUPAC Name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- Details on test material:
- - Name of test material (as cited in study report): API# 81-09 (CAS# 64742-80-9)
- Substance type: clear liquid
- Physical state: liquid
- Analytical purity: to be determined by the sponsor
- Impurities (identity and concentrations): to be determined by the sponsor
- Stability under test conditions: to be determined by the sponsor
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Labs, Portage, Michigan
- Age at study initiation: Approximately 7 weeks of age
- Weight at study initiation: Male - 246 grams, Females - 191 grams
- Fasting period before study: food was removed overnight prior to initiation
- Housing: group cages prior to initiations and individually housed after initiation
- Diet (e.g. ad libitum): Purina certified rodent chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68.0 to 73.4°F
- Humidity (%): 32 to 64%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1982-01-07 To: 1982-01-21
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
No vehicle used
MAXIMUM DOSE VOLUME APPLIED: 6.10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: greater than 5.0 g/kg of body weight - Doses:
- 6.10 mL/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed hourly during first 6 hours after initiation then twice daily. Weighed during pre-fast, initiation, after 7 days and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: pharmacotoxic signs - Statistics:
- Not Performed
Results and discussion
- Preliminary study:
- Not conducted
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- There was no mortality at the 5,000 mg/kg bw dose.
- Clinical signs:
- other: Pharmacotoxic signs observed included hypoactivity, urine stained abdomen and oily looking hair.
- Gross pathology:
- Two animals had mildly enlarged cervical lymph nodes, one stomach distended with red-brown material, one left kidney-renal pelvis moderately dilated, one alopecia on entire stomach area.
- Other findings:
- Not Reported
Any other information on results incl. tables
|
Dosage Level |
Average Body Weights (g) |
|||
(g/kg) |
Pre-Fast |
Initial |
7 Days |
14 Days |
|
Males |
5.0 |
271 |
246 |
295 |
326 |
Females |
5.0 |
215 |
191 |
228 |
241 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 was determined to be > 5,000 mg/kg bw in males and females.
- Executive summary:
In an acute oral toxicity study, groups of fasted, 7-week old, Albino Sprague-Dawley rats 5 males and 5 females were given a single oral dose of undiluted hydrodesulfurised middle distillate at doses of 6.10 mL/kg (>5,000 mg/kg bw) and observed for 14 days.
There was no mortality or abnormal changes in body weight. Treatment related clinical signs included hypoactivity, urine stained abdomen, and oily looking hair. Necropsy findings on the animals revealed two mildly enlarged cervical lymph nodes, a distended stomach, renal pelvis moderately dilated, and alopecia on the stomach area. The oral LD50 was determined to be > 5,000 mg/kg bw in males and females.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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