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EC number: 203-528-1 | CAS number: 107-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
- Species:
- guinea pig
- Strain:
- not specified
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Irritation parameter:
- other:
- Basis:
- other:
- Remarks on result:
- other: Scoring was based on observation and not done with a numerical scale
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Methyl n-propyl ketone was considered to be a skin irritant.
- Executive summary:
Methyl n-propyl ketone was applied to the skin of Guinea Pigs. The test article was considered to be a slight skin irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was done in a GLP facility to OECD guidelines
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4500 (Acute Eye Irritation)
- Deviations:
- not applicable
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- SPECIES: Rabbit
STRAIN/SOURCE: New Zealand White, HRP, Inc. (Denver, PA)
AGE ON RECEIPT: At least 16 weeks
NUMBER AND SEX: 6 females (nulliparous and non-pregnant)
WEIGHT: 2.47- 2.93 kg at receipt
IDENTIFICATION: Unique number written in one ear with an indelible marker and corresponding cage card
JUSTIFICATION OF USE: The rabbit is the recommended species for this test
The rabbits were held in quarantine for approximately 7 days after receipt. They were housed individually in stainless steel cages with screen-bottom floors. Environmental controls maintained temperatures of 60.8- 69.8°F, and humidity at 50± 10%. A 12-hour light:dark cycle was maintained. Air flow was regulated at 1 0 or more air changes per hour. - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Each animal received 0.1 ml of the test substance, which was instilled into the conjunctival sac of the left eye. The lids were held closed for 1 second to prevent loss of the material. The other eye was untreated and served as a control.
- Duration of treatment / exposure:
- All treated eyes were examined for ocular irritation at 1, 24, 48, 72 and 96 hours and 7 days after
instillation. - Observation period (in vivo):
- All treated eyes were examined for ocular irritation at 1, 24, 48, 72 and 96 hours and 7 days after
instillation. - Number of animals or in vitro replicates:
- 6 Female rabbits
- Details on study design:
- Six naive female rabbits, free of ocular irritation, were assigned to the study. Each animal received 0.1 ml of the test substance, which was instilled into the conjunctival sac of the left eye. The lids were held closed for 1 second to prevent loss of the material. The other eye was untreated
and served as a control. All treated eyes were examined for ocular irritation at 1, 24, 48, 72 and 96 hours and 7 days after instillation. Sodium fluorescein stain was used at all examinations except at one hour. Irritation was graded and scored by the Draize technique. A rating was assessed using the method of Draize, Woodard and Calvery and assigned a category as used by the EPA. Clinical observations recorded once daily included, but were not limited to:
A. Any response with respect to body position, activity, coordination, or gait.
B. Any unusual behavior such as head flicking, compulsive biting or licking, circling, etc.
C. The presence of: Convulsions or tremors, increased salivation, increased lacrimation, increased or decreased urination or defecation (including diarrhea), piloerection, mydriasis or miosis (enlarged or constricted pupils), unusual respiration (fast, slow, gasping, or retching), unusual vocalization.
On SO 9, all the animals on study were killed with an overdose of sodium pentobarbital and discarded. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.7
- Max. score:
- 80
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1.7
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2.6
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US OSHA
- Conclusions:
- A maximum mean irritation index of 12.83/110, calculated at one hour, classifies Eastman MPK as
mildly irritating. The presence of positive corneal and iris responses also classifies the material as a
positive irritant. Since all effects had cleared in 7 days, the material is a Category Ill substance. - Executive summary:
Six female rabbits were exposed to 0.1 ml of Eastman MPK which was instilled into the conjunctival sac of one eye. Observations to detect ocular irritation were made at 1 , 24, 48, 72 and 96 hours and 7 days after exposure. The study ended on SD 9. The rabbits were killed with an overdose of sodium pentobarbital and discarded. Eastman MPK is a mildly irritating substance, based on a maximum mean irritation index of 12.83/11.0 , calculated at one hour after exposure. Positive corneal and iris responses were observed in 6/6 and 3/6 treated eyes, respectively. Conjunctivitis was also noted in 6/6 rabbit eyes. Recovery from the ocular effects was noted in all animals at 7 days. Eastman MPK is a positive irritant, and is a Category Ill substance
Reference
All of the eyes exposed to Eastman MPK developed a mild corneal opacity within 1-96 hours after instillation. The opacities were never more severe than Grade 1, and generally covered 1/2- 3/4 of the corneal surface. Positive uptake of the sodium fluorescein did indicate sloughing of the corneal epithelium. Three of the six treated eyes also exhibited a positive iris score. Conjunctival irritation was most prominent at the 1, 24 and 48 hour examinations, and consisted of mild redness, chemosis and discharge. Recovery from the ocular effects was observed in all rabbits at 7 days. A maximum mean irritation index of 12.83/110, calculated at one hour, classifies Eastman MPK as mildly irritating. The presence of positive corneal and iris responses also classifies the material as a positive irritant. Since all effects had cleared in 7 days, the material is a Category Ill substance
SUMMARY OF OCULAR SCORING | |||||||
Animal Number | Group-Sex | 1Hr | SD 1 | SD 2 | SD 3 | SD 4 | SD 7 |
H931 | Group 1 - Female | 6 | 12 | 0 | 0 | 0 | 0 |
H932 | Group 1 - Female | 6 | 7 | 2 | 0 | 0 | 0 |
H933 | Group 1 - Female | 10 | 22 | 2 | 0 | 0 | 0 |
H934 | Group 1 - Female | 18 | 4 | 2 | 5 | 0 | 0 |
H935 | Group 1 - Female | 25 | 2 | 7 | 0 | 0 | 0 |
H936 | Group 1 - Female | 12 | 2 | 2 | 0 | 10 | 0 |
Group 1 | Mean Score | 12.83 | 8.17 | 2.5 | 0.83 | 1.67 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Methyl n-Propyl Ketone was moderately irritating to the eyes of rabbits and slightly irritating to the skin of guinea pigs. The studies were done prior to GLP so the reports are lacking in documentation, but they were conducted in a high quality facility to the standards of the day.
Justification for selection of eye irritation endpoint:
The study was a modern, well documented study. Study .001 lacked documentation and detail to establish classification.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: moderately irritating
Justification for classification or non-classification
Acute eye irritation testing supports a category 2 classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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