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EC number: 700-534-0 | CAS number: 117172-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Local Lymph Node Assay according to OECD 429 and Commission Regulation (EC) No 440/2008 of 30 May 2008, B.42 was performed with CBA/J@Rj mice. The aim of this study was to determine the skin sensitisation potential of Intermediate 36 following dermal exposure in the Local Lymph Node Assay. The test item was a light yellow liquid; vehicle compatibility was verified in a
Preliminary Compatibility Test with Acetone: Olive oil 4:1 mixture (AOO). The maximum available concentration was 100% in this vehicle. A Preliminary Irritation/Toxicity test was performed with the test item at concentrations of 100 % and 50 % in the selected vehicle. The applicability and biocompatibility of the test item on the ears of animals at the maximum concentration of test item of 100 % was acceptable. In the main assay twenty female CBA/J@Rj mice were allocated to 6 groups / 4 animals each:
- 3 groups received the appropriate formulation of Intermediate 36 at concentrations of 100 %, 50 %, 25 % and 10 %,
- the negative control group received the vehicle (AOO),
- the positive control group received 25 (w/v) % HCA in AOO
The test item solutions were applied on the dorsal surface of ears of experimental animals (25 l/ear) for three consecutive days (Days 1, 2 and 3). There was no treatment on Days 4, 5 and 6. On Day 6, the cell proliferation in the local lymph nodes was measured by incorporation of tritiated methyl thymidine (3HTdR) and the values obtained were used to calculate stimulation indices (SI).
No mortality or systemic clinical signs were observed during the study. No treatment related effect on the body weights was observed. Erythema and coated fur were observed in the 100 %, 50 % and 25% treated groups, erythema was observed at the 10 % treated group. Stimulation index values of the test item were 55.4, 91.5, 91.8, and 76.6 at treatment concentrations of 100, 50 %, 25 % and 10 %, respectively. α-Hexylcinnamaldehyde (25 (w/v) % dissolved in AOO) was used as a positive control to demonstrate the appropriate performance of the assay. A significant lymphoproliferative response (stimulation index value of 10.1) was noted for the positive control chemical and this result confirmed the validity of the assay.
In conclusion, under the conditions of the present assay Intermediate 36, tested in a suitable vehicle, was shown to have a strong sensitisation potential (sensitiser) in the Local Lymph Node Assay.
Migrated from Short description of key information:
Local Lymph Node Assay according to OECD 429 and Commission Regulation (EC) No 440/2008 of 30 May 2008, B.42 was performed with CBA/J@Rj mice. Under the conditions of the present assay Intermediate 36, tested in a suitable vehicle, was shown to have a strong sensitisation potential (sensitiser) in the Local Lymph Node Assay.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data
Migrated from Short description of key information:
no data
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.