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EC number: 273-110-1 | CAS number: 68938-03-4 The complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isononanal. It consists predominantly of C6 olefins and paraffins and C9 alcohols and aldehydes and boiling in the range of approximately 110°C to 202°C (230°F to 396°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 January 2010 to 3 February 2010 (in-life phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study undertaken according to current OECD and EU Test Guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, Test Data for Registration of Agricultural Chemicals, Acute dermal toxicity (2-1-2), 12 Nohsan No 8147, Agricultural Production Bureau, November 24, 2000.
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Octene, hydroformylation products, low-boiling
- EC Number:
- 273-110-1
- EC Name:
- Octene, hydroformylation products, low-boiling
- Cas Number:
- 68938-03-4
- IUPAC Name:
- Octene, hydroformylation products, low-boiling
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Oxooil LS9
- Substance type: Industrial
- Physical state: liquid
- Analytical purity: 95.3%
- Impurities (identity and concentrations): no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: 13.06.2008 0649/82531
- Expiration date of the lot/batch: 8 June 2010
- Stability under test conditions: no data
- Storage condition of test material: refrigerated, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd.
- Age at study initiation: 8 to 12 weeks
- Weight at study initiation: 207 to 339 g
- Fasting period before study: none
- Housing: individually in solid bottomed polycarbonate cages
with a stainless steel mesh lid
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23°C
- Humidity (%): 40-70 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: 14 January 2010 (animal allocation) To: 3 February 2010 (terminal necropsy)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorso-lumbar region (approximately 50 mm x 50 mm)
- % coverage: 10% of total body surface area
- Type of wrap if used: porous gauze held in place with a non-irritating dressing, and further covered by a waterproof dressing encircled firmly around the trunk of the animal
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.74 ml/kg bodyweight
- Constant volume or concentration used: test material used as supplied (SG 0.73 g/ml) - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- 5 male and 5 female animals
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1. On subsequent days, animals were observed once in the morning and again at the end of the experimental day (with the exception of Day 15 - morning only). Local dermal irritation at the treatment site was assessed daily. The weight of each rat was recorded on Days 1 (prior to dosing), 8 and 15.
- Necropsy of survivors performed: yes - Statistics:
- Not undertaken
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/5 males and 0/5 females
- Clinical signs:
- other: There were no clinical signs considered to be related to treatment. There were no deaths and no clinical signs considered to be related to treatment. Very slight or well-defined erythema was observed in four males and three females from Day 2. These react
- Gross pathology:
- A small stomach was noted in one female at the macroscopic examination on Day 15. No
macroscopic abnormality was noted in any other animal.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal dermal dose (LD50) to rats of Oxoil LS9 was demonstrated to be greater than 2000 mg/kg bodyweight.
- Executive summary:
A study was performed at the Laboratories of Huntingdon Life Sciences, Alconbury, on behalf of Evonik Oxeno GmbH., to assess the acute dermal toxicity of the test substance Oxooil LS9. The study was conducted to GLP and in accordance with OECD Guideline 402 and EU Method B.3. The test substance was administered to the clipped dorsal skin of 5 male and 5 female rats at a dosage of 2000 mg/kg bodyweight under occlusive dressings for 24 hours (Limit test). Systemic and local signs of reaction to treatment were recorded at least once daily for 14 days following removal of the dressings. There were no deaths and no systemic signs of reaction to treatment. Very slight or well-defined erythema, from Day 1 to 8, desquamation (exfoliation), from Day 5 to 9, and scabbing from Day 4 to 14, were observed amongst four male and four females rats. One female rat was considered to have low bodyweight gain during Days 1 to 8.
The acute dermal median lethal dosage (LD50) to rats of Oxooil LS9 was demonstrated to be greater than 2000 mg/kg bodyweight.
The study is considered acceptable for classification and satisfies the guideline requirements for a rat acute dermal toxicity test.
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