3,3'-[butane-1,4-diylbis(oxy)]bispropanamine

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

BASF test

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,3'-[butane-1,4-diylbis(oxy)]bispropanamine

EC Number:

230-745-9

EC Name:

3,3'-[butane-1,4-diylbis(oxy)]bispropanamine

Cas Number:

7300-34-7

Molecular formula:

C10H24N2O2

IUPAC Name:

3-[4-(3-aminopropoxy)butoxy]propan-1-amine

Specific details on test material used for the study:

- Name of test material (as cited in study report): Butandiol-di(aminopropyl)-ether
- Physical state: liquid

Test animals

Species:

mouse

Strain:

other: Kisslegg

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: males: 28.7 g; females: 25.1 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Details on exposure:

- Concentraion of test substance in vehicle: 2% (v/v)

Doses:

100, 125, 160, 200, 250, 320, 400 µL/kg bw
99, 120, 154, 192, 240, 307, 384 mg/kg bw (calculated from original values using density of 0.96 g/cm³)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 120 mg/kg bw

Remarks on result:

other: calculated from original value ca. 125 µL/kg bw using density of 0.96 g/cm³

Clinical signs:

At all doses immediately after injection spastic gait, dyspnoea, tremor. From day 11 on no symptoms in surviving animals.

Gross pathology:

Hyperaemia in the liver, intra-abdominal adhesions.

Any other information on results incl. tables

Mortality data:

Dose [cmm/kg]	Mortality
	Male	Female
400	5/5	5/5
320	5/5	5/5
250	5/5	5/5
200	5/5	5/5
160	3/5	1/5
125	2/5	3/5
100	0/5	0/5